Skip to main content
SpringerLink
Log in

Bakteriologische Prüfung von Cefotaxim, einem neuen halbsynthetischen Cephalosporin, im Rahmen der Routinediagnostik

Bacteriological testing of cefotaxime, a new semisynthetic cephalosporin, in routine diagnostics

  • Mikrobiologie
  • Published:
Infection Aims and scope Submit manuscript

Zusammenfassung

7973 Bakterienstämme aus der Routinediagnostik wurden auf ihre Empfindlichkeit gegenüber dem neu entwickelten Antibiotikum Cefotaxim geprüft. Im Vergleich zu den bisher gebräuchlichen Cephalosporinen zeigte Cefotaxim eine Erweiterung des Wirkungsspektrums auf die Hälfte derPseudomonas aeruginosa-Stämme und eine bei vielen Spezies erhöhte antibakterielle Aktivität. Die Resistenzsituation in verschiedenen medizinischen Bereichen war unterschiedlich. Die höchsten Resistenzquoten fand man auf der operativen Intensivstation.

Summary

7973 bacterial strains obtained in routine diagnostics were studied in order to determine their sensitivity to cefotaxime, a newly developed antibiotic. Compared to the cephalosporins in use up until now, cefotaxime displayed an enlarged spectrum of effectiveness to include half of thePseudomonas aeruginosa strains and increased antibacterial activity against many species. Resistance varied for different fields of medicine. The highest resistance quotes were found in the surgical intensive care unit.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Fu, K. P., Neu, H. C. Beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin. Antimicrob. Agents Chemother. 4 (1978) 437–444.

    Google Scholar 

  2. Ericsson, H. M., Sherris, J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Path. Microbiol. Scand. B Suppl. 217 (1971) 1–90.

    Google Scholar 

  3. Linzenmeier, G., Rosenthal, E. Zur In-vitro-Testung der neueren Cephalosporine. Infection 7 Suppl. 2 (1979) 225–227.

    Google Scholar 

  4. Chabbert, Y. A., Lutz, A. J. HR 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity. Antimicrob. Agents Chemother. 14 (1978) 749–754.

    Google Scholar 

  5. Drasar, F. A., Farell, W., Howard, A. J., Hince, C., Leung, T., Williams, J. D. Activity of HR 756 againstHaemophilus influenzae, Bacteroides fragilis and gram-negative rods. J. Antimicrob. Chemother. 4 (1978) 445–450.

    Google Scholar 

  6. Shah, P. M., Troche, G., Stille, W. In vitro activity of HR 756, a new cephalosporin compound. J. Antibiot. 31 (1978) 1170–1174.

    Google Scholar 

  7. Sosna, J. P., Murray, P. R., Medoff, G. Comparison of the in vitro activities of HR 756 with cephalothin, cefoxitin and cefamandole. Antimicrob. Agents Chemother. 14 (1978) 876–879.

    Google Scholar 

  8. Wise, R., Rollason, T., Logan, M., Andrews, J. M., Bedford, K. A. HR 756, a highly active cephalosporin: comparison with cefazolin and carbenicillin. Antimicrob. Agents Chemother. 14 (1978) 807–811.

    Google Scholar 

  9. Lübcke, P., Freitag, V. Aktueller Stand der Chemotherapie bei Infektionen in der internistischen Intensivmedizin. Intensivmed. 15 (1978) 263–265.

    Google Scholar 

  10. Freitag, V. Resistenzsituation bestimmterEnterobacteriaceae im Krankenhaus und in der Ambulanz. Münch. med. Wschr. 118 (1976) 275–278.

    Google Scholar 

  11. Knothe, H., Sietzen, W. Mikrobiologische Überlegungen beim Einsatz von Antibiotika auf Intensivabteilungen. Infection 7 Suppl. 2 (1978) 191–193.

    Google Scholar 

  12. Legler, F. Antimikrobielle Chemotherapie vor Erregernachweis und Antibiogramm? Med. Klin. 72 (1977) 813–818.

    Google Scholar 

  13. Ullmann, U. Erregerspektrum und Resistenzsituation bei Bakteriurie hospitalisierter Patienten. Immun. Infekt. 6 (1977) 252–257.

    Google Scholar 

  14. Shah, P. M., Helm, E. B., Stille, W. Klinische Erfahrungen mit Cefotaxim. einem neuen Cephalosporin-Derivat. Med. Welt 30 (1979) 298–301.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Allgemeines Krankenhaus Altona, Paul-Ehrlich-Str. 1, D-2000, Hamburg 50

    V. Freitag,  O. Friedrich,  P. -O. Kopf &  D. H. Wittmann

Authors
  1. V. Freitag
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Friedrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. -O. Kopf
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. H. Wittmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Herrn Prof. Dr.Blunck sei an dieser Stelle gedankt.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freitag, V., Friedrich, O., Kopf, P.O. et al. Bakteriologische Prüfung von Cefotaxim, einem neuen halbsynthetischen Cephalosporin, im Rahmen der Routinediagnostik. Infection 8 (Suppl 4), S397–S400 (1980). https://doi.org/10.1007/BF01639406

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01639406

Search

Navigation