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Ampicillin-gentamicin synergism against Listeria monocytogenes in vitro

Ampicillin-Gentamicin Synergismus gegen Listeria monocytogenes in vitro

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Summary

Forty-five isolates ofListeria monocytogenes were investigated for evidence of ampicillin-gentamicin synergism usingin vitro killing curve techniques. All organisms tested demonstrated the phenomenon even though only sub-cidal concentrations of antibiotics were used. Clinical studies comparing the use of the combination versus ampicillin alone are probably indicated.

Zusammenfassung

45 Isolate vonListeria monocytogenes wurden bezüglich einer synergistischen Wirkung von Ampicillin-Gentamicin durch Bestimmung der In-vitro-Abtötungskurven untersucht. Bei allen untersuchten Stämmen war ein Synergismus nachzuweisen, obwohl nur Antibiotika-Konzentrationen verwendet wurden, die unterhalb der bakteriziden Konzentration lagen. Es ist wahrscheinlich gerechtfertigt, klinische Studien durchzuführen, die die Antibiotika-Kombination mit Ampicillin allein vergleichen.

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Authors and Affiliations

  1. Department of Pediatrics/Human Development, Michigan State University and Department of Pediatrics, Saginaw Cooperative Hospitals, 1000 Houghton St., 48602, Saginaw, Michigan, USA

    R. C. Gordon,  R. E. Wofford,  T. Hsu &  L. L. Fechner

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  1. R. C. Gordon
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  2. R. E. Wofford
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  3. T. Hsu
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  4. L. L. Fechner
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Gordon, R.C., Wofford, R.E., Hsu, T. et al. Ampicillin-gentamicin synergism against Listeria monocytogenes in vitro. Infection 8, 221–222 (1980). https://doi.org/10.1007/BF01639039

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  • DOI: https://doi.org/10.1007/BF01639039

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