Summary
The hemolytic action of a homologous series of sodium alkyl sulfates (C 8 toC 15) on dog and human erythrocytes was measured. The influence of trypsin, pronase and neuraminidase treatments on the lytic resistance of human red cells was studied. A new approach evaluating the hemolytic activity of ionic detergents is expressed as a ratio of a concentration providing 50% lysis to its CMC-value. The results obtained are examined for their bearing on the use of surface-active agents as a means to study the structure organization of biological membranes.
Zusammenfassung
Es wurde die hämolytische Wirkung homologer Reihen von Natriumalkylsulfaten an Erythrozyten von Mensch und Hund gemessen. Um die hämolytische Aktivität der ionogenen Detergenzien zu charakterisieren, wurde das Verhältnis der Konzentration, welche eine 50%-ige Lyse bewirkt, zum cmc-Wert gewählt.
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Ossipov, N.N., Zaslavsky, B.Y. & Rogozhin, S.V. Action of surface-active substances on biological membranes I. Effect of chemical modification of membranes on hemolysis of erythrocytes by sodium alkyl sulfates. Colloid & Polymer Sci 256, 1105–1109 (1978). https://doi.org/10.1007/BF01638303
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DOI: https://doi.org/10.1007/BF01638303