Abstract
The effects of 6-h hypothermic cardioplegic arrest on myocardial biochemical, morphologic, and functional recovery were investigated in two groups of dogs. Group 1 (n = 6) was subjected to hypothermia of 15°C and group 2 (n = 6) was subjected hypothermia of 5°C. Although the myocardial calcium (Ca) concentration was significantly higher at the end of reperfusion in group 2 compared to group 1, the MB-fraction of creatine kinase, mitochondrial aspartate aminotransferase, recovery of left ventricular systolic function, and mitochondrial morphologic integrity were better in group 2 than in group 1. These findings suggest that hypothermia of 5°C in 6-h cardioplegia is not necessarily coupled with interference in myocardial contractility, despite the Ca overload that occurs during reperfusion.
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Sunamori, M., Amano, J. & Suzuki, A. The effects of a temperature below 15°C on the myocardial calcium and ultrastructure in donor heart preservation in a canine model. Surg Today 24, 809–814 (1994). https://doi.org/10.1007/BF01636311
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DOI: https://doi.org/10.1007/BF01636311