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Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity

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Summary

Intravenous polymethacrylic acid (PMAA) significantly increases the number of lymphocytes in the blood of the rat. The relationship between dose-effect and lymphocytosis is linear. The lethal dose in 30 days of PMAA is 120 mg/kg b. w. and the half-lethal dose 80 mg/kg b. w. The treatment with 40 mg/kg b. w. intiavenous PMAA gives no toxic histological changes either in the lymph organs, the liver or the kidneys. Thus, PMAA appears to be, at present, a most suitable agent by which to provoke experimentally, migration of the reserve lymphocytes into the blood.

Zusammenfassung

Intravenös verabreichte Polymethacrylsäure (PMS) führt zu einer wesentlichen Erhöhung der Lymphozytenzahl im Blut der Ratte. Das Verhältnis zwischen Dosiswirkung und Lymphozytose ist linear. Die Letaldosis im Verlauf von 30 Tagen beträgt 120 mg PMS pro kg Körpergewicht und die LD50 80 mg/kg Körpergewicht. Die intravenöse Behandlung mit 40 mg/kg Körpergewicht ergibt keine toxischen histologischen Veränderungen im Lymphsystem, der Leber oder der Niere. PMS erscheint daher gegenwärtig als bestens geeignetes Mittel, experimentell eine Wanderung der Reservelymphozyten in das Blut zu bewirken.

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  1. S. Ormai M. D., C. SC.

    Present address: Institute of Experimental Medicine, Hungarran Academy of Sciences, P. O. Box 67, H-1450, Budapest, Hungary

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  1. Institute of Experimental Medicine, Hungarran Academy of Sciences, P. O. Box 67, H-1450, Budapest, Hungary

    M. Palkovits

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  1. S. Ormai M. D., C. SC.
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Ormai, S., Palkovits, M. Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity. Blut 31, 239–246 (1975). https://doi.org/10.1007/BF01633507

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  • DOI: https://doi.org/10.1007/BF01633507

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