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Immunoadherence and post-transfusion reactions

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Summary

In blood samples taken during or right after transfusion reactions not caused by blood group incompatibility, it is possible to isolate in 5 out of 43 cases blood cells that were IA-reactive after treatment with guinea-pig complement and that were able to agglutinate human indicator O-erythrocytes. In contrast it is impossible to show IA-reactive complexes in plasma. This indicates that at least with part of the posttransfusion reactions IA is involved.

Zusammenfassung

Aus Blutproben, die während oder unmittelbar nach nicht durch Blutgruppenunverträglichkeit bedingten, ihrer Symptomatik nach allergischen Transfusionsreaktionen entnommen wurden, ließen sich in 5 von 43 Fällen Zellen isolieren, welche nach geeigneter Präparation und Zusatz von Meerschweinchen-Komplement immunadhärenz-(IA)-reaktiv und dadurch fähig waren, als Indikatorteilchen verwendete menschliche O-Erythrozyten zu agglutinieren. Dagegen gelingt es nicht, im Plasma der gleichen Blutproben IA-reaktive Komplexe nachzuweisen. Dies deutet darauf hin, daß zumindest in einem Teil der unaufgeklärten Transfusionsreaktionen auch Immunadhärenz-Reaktionen eine Rolle spielen können.

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  1. Volkmar Sachs

    Present address: Department of Blood Transfusion, Institute of Hygiene, University of Kiel, Brunswiker Str. 2-6, 23, Kiel, BRD

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    1. Volkmar Sachs
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    Sachs, V. Immunoadherence and post-transfusion reactions. Blut 26, 388–392 (1973). https://doi.org/10.1007/BF01632748

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    • DOI: https://doi.org/10.1007/BF01632748

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