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The use of human AHF (fraction I-0) in haemophilia A

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Summary

Human fraction I-0, containing AHF, prepared by the glycine method ofBlombäck a.Blombäck, has been given on 818 occasions to 63 patients with haemophilia A. The patients were treated in connexion with major and minor surgical procedures and bleeding episodes, such as gastrointestinal, retroperitoneal, renal and joint bleeding. It is shown that fraction I-0 can be used with advantage to treat bleedings in haemophiliacs, to prepare them for operations and to promote subsequent healing.

Zusammenfassung

Nach der Glykokoll-Methode vonBlombäck u.Blombäck wurde menschliche Fraktion I-0, welche AHF enthält, hergestellt. Das Präparat wurde bei 63 Patienten mit Hämophilie A über 818 mal appliziert. Die Patienten wurden anläßlich Eingriffen der großen und kleinen Chirurgie sowie bei Blutungsepisoden mit gastrointestinalen, retroperitonealen, renalen und articulären Blutungen behandelt. Es ließ sich nachweisen, daß die Fraktion I-0 bei Hämophilen mit Vorteil bei Blutungen, zur Vorbeteitung zu Operationen und zur Beschleunigung der folgenden Wundheilung angewandt werden kann.

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References

  1. Biggs R. a. R. G. MacFarlane: Human Blood Coagulation and its Disorders. Second Edition. 476 pp. Blackwell, Oxford 1957.

    Google Scholar 

  2. Blombäck B. a. M. Blombäck: Purification of human and bovine fibrinogen. Ark. Kemi10, 415–443 (1956).

    Google Scholar 

  3. Blombäck M.: Purification of antihemophilic globulin. I. Some studies on the stability of the antihemophilic globulin activity in fraction I-0 and a method for its partial separation from fibrinogen Ark. Kemi12, 387–396 (1958).

    Google Scholar 

  4. Blombäck M.: Studies on antihemophilic globulin. Acta paediat., Uppsala,47: Suppl. 114, 1–32 (1958). (Thesis).

    Google Scholar 

  5. Blombäck M., B. Blombäck, E. Jorpes a. I. M. Nilsson: On the preparation of human antihaemophilic globulin. Proc. 7th Congr. Europ. Soc. Haemat. London 1959, S. Karger, Basel 1960.

    Google Scholar 

  6. Blombäck M. a. I. M. Nilsson: Treatment of hemophilia A with human antihemophilic globulin. Acta Med. Scand.161: 301–321 (1958).

    Article  PubMed  Google Scholar 

  7. van Creveld, S. a. I. A. Mochtar: Management of Hemophilia. Hemophilia and other Hemorrhagic States. Chapel Hill, University of North Carolina Press, 1957.

    Google Scholar 

  8. Jorpes J. E., B. Blombäck, M. Blombäck a. S. Magnusson: A pilot plant for the preparation of a plasma fraction containing the human antihaemophilic factor A (factor VIII). Acta Med. Scand. Suppl. 1962.

  9. McMillan C. W., L. K. Diamond a. D. M. Surgenor: Treatment of classic hemophilia: The use of fibrinogen rich in factor VIII for hemorrhage and for surgery. New Engl. J. Med.265, 224–230, 277–283 (1961).

    Article  Google Scholar 

  10. Nilsson I. M.: Ein Fall weiblicher Hämophilie und dessen Behandlung mit speziell hergestelltem, menschlichem Antihämophilieglobulin. Symposion über Nebenwirkungen von Arzneimitteln auf Blut und Knochenmark. 3.–7. Juni 1956, Malmö Schattauer-Verlag, Stuttgart 1957.

    Google Scholar 

  11. Nilsson I. M., M. Blombäck a. B. Blombäck: v. Willebrand's disease in Sweden. Its pathogenesis and treatment. Acta Med. Scand.164: 263–278 (1959).

    Article  CAS  PubMed  Google Scholar 

  12. Nilsson I. M., M. Blombäck a. B. Blombäck: The use of Human Anti-haemophilic Globulin (Fraction I-0) in Haemophilia A and in von Willebrand's Disease. Proc. 7th Congr. Europ. Soc. Haemat., London 1959; Acta haemat.24, 116–123 (1960).

    Article  Google Scholar 

  13. Nilsson I. M., B. Blombäck, M. Blombäck a. S. Svennerud: Kvinnlig hämofili och dess behandling med humant antihämofiliglobulin. Nord. Med.56, 1654–1659 (1956).

    PubMed  Google Scholar 

  14. Nilson I. M., M. Blombäck, E. Jorpes, B. Blombäck a. S.-A. Johansson: v. Willebrand's disease and its correction with human plasma fraction I-0. Acta Med. Scand.159, 179–188 (1957).

    Article  Google Scholar 

  15. Nilsson I. N., M. Blombäck a. I. von Francken: On an inherited autosomal hemorrhagic diathesis with antihemophilic globulin (AHG) deficiency and prolonged bleeding time. Acta Med. Scand.159, 35–57 (1957).

    Article  CAS  PubMed  Google Scholar 

  16. Nilsson I. M., M. Blombäck a. I. v. Francken: On an inherited autosomal haemorrhagic diathesis with antihaemophilic globulin deficiency and prolonged bleeding time. Proc. 6th Congr. Europ. Soc. Haemat. Copenhagen 1957,2, 629–636. S. Karger, Basel 1958.

    Google Scholar 

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Author notes

  1. Inga Marie Nilsson

    Present address: Allmänna Sjukhuset, Malmö, Schweden

Authors and Affiliations

  1. Department of Medicine, University of Lund, Lund, Sweden

    Inga Marie Nilsson, Margareta Blombäck, Birger Blombäck & Olof Ramgren

  2. Allmänna Sjukhuset, Malmö, Schweden

    Margareta Blombäck, Birger Blombäck & Olof Ramgren

  3. the Chemistry Department II, Karolinska Institutet, Stokholm, Sweden

    Inga Marie Nilsson, Margareta Blombäck, Birger Blombäck & Olof Ramgren

Authors
  1. Inga Marie Nilsson
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  2. Margareta Blombäck
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  3. Birger Blombäck
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  4. Olof Ramgren
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Additional information

This investigation was supported by grants from the Swedish Medical Research Council, Harald och Greta Jeansson Stiftelse, Stiftelsen Gustaf och Tyra Svensson Minne, Karolinska Institutet, Research Grants No 4295 (R 1, C 1 and C 2) from the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Syskonen Wesséns Stiftelse and Knut och Alice Wallenbergs Stiftelse, Stockholm.

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Nilsson, I.M., Blombäck, M., Blombäck, B. et al. The use of human AHF (fraction I-0) in haemophilia A. Blut 8, 92–101 (1962). https://doi.org/10.1007/BF01630381

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