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Neue Ergebnisse der Hämophilie-Forschung

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Literatur

  1. Aggeler, P. W., White, S. G., Glendening, M. B., Page, E. P., Leake, T. B., Bates, G.: Plasma Thromboplastin Component (PTC) deficiency: A new disease resembling hemophilia. Proc. Soc. Exper. Biol. a. Med., 79, 692 (1952).

    Google Scholar 

  2. Aggeler, P. W. usw.: PTC factor deficiency: A previously undescribed hemophilia-like disease due to deficiency of a heretofore unknown thromboplastin component. Am. J. Med. 13. 90 (1952).

    Google Scholar 

  3. Aggeler, P. M., S. G. White, T. H. Spaet: Deuterohemophilia: Plasma thromboplastin factor B deficiency, Plasma thromboplastin component (PTC) deficiency, Christmas disease, Hemophilia B. Blood 9, 246 (1954).

    Google Scholar 

  4. Aggeler, P. M., Spaet, T. H., Emery, B. E.: Purification of plasma thromboplastin factor B and its identification as Betas globulin. Science 119, 806 (1954).

    Google Scholar 

  5. Alexander, B., Goldstein, R., Landwehr, G., Cook, C. D.: Congenital SPCA deficiency: A hitherto unrecognized coagulation defect with hemorrhage rectified by serum and serum fractions. J. Clin. Invest. 30, 596 (1951).

    Google Scholar 

  6. Alexander, B., Goldstein, R.: Parahemophilia in three siblings (Orwen's disease), with studies on certain plasma components affecting prothrombin conversion. Am J. Med. 13, 255 (1952).

    Google Scholar 

  7. Alexander, B.: Some biochemical, physiological and pathological aspects of the coagulation mechanism. In: Symposium II: Blood cells and plasma proteins: Their state in nature. Harvard Memoirs, New York 1953.

  8. Alexander, B., Goldstein, R., Rich, L., DeBoiloch, A. G., Diamond, L. K., Barges, W.: Congenital afibrinogenemia. A study of some basic aspects of coagulation. Blood IX, 843–864 (1954).

    Google Scholar 

  9. Beaumont, J. C., Cayla, A., Dupin, H., Bernard, J.: Syndrome hémorrhagique du facteur antihémophilique (Hémophilie B). Sang 24, 488 (1953).

    Google Scholar 

  10. Bell, W. N., Alton, H. G.: A brain extract as a substitute for platelet suspensions in the thromboplastin generation test. Nature 174, 880–881 (1954).

    Google Scholar 

  11. Benfeld, P., Stefanini, M., Berkowitz, R. D., Hennessey, F. B.: Electrophoretic plasma protein patterns in families with hemophilia. Proc. Soc. Exp. Biol. u. Med. 83, 311 (1953).

    Google Scholar 

  12. Bergsagel, D. E., Setna, S. S., Cartwright, G. E., Wintrobe, M. M.: Mild PTC (Plasma thromboplastin component) deficiency occuring in two brothers. Blood 9, 866 (1954).

    Google Scholar 

  13. Bergsagel, D. E.: The role of calcium in the activation of the Christmas factor. Brit. J. Hämatolog. 1. 199–212 (1955).

    Google Scholar 

  14. Bidwell, E.: The purification of bovine antihaemophilic globulin. Brit. J. Haematolog. 1, 35 (1955).

    Google Scholar 

  15. Biggs, R., Douglas, A. S., Macfarlane, R. G., Dacie, J. V., Pitney, W. R., Merskey, C., O'Brian, J. R.: Christmas disease; a condition previously mistaken for hemophilia. Brit. Med. J. 2, 1378 (1952).

    Google Scholar 

  16. Biggs, R., Douglas, A. S., Macfarlane, R. G.: Christmas disease. Brit. Med. J. 1, 221 (1953).

    Google Scholar 

  17. Biggs R., Douglas, A. S., Macfarlane, R. G.: The formation of thromboplastin in human blood. J. Physiolog. 119, 89 (1953).

    Google Scholar 

  18. Biggs, R., Douglas, A. S., Macfarlane, R. G.: The action of thromboplastin substances. J. Physiolog. 122, 554 (1953).

    Google Scholar 

  19. Biggs, R., Douglas, A. S., Macfarlane, R. G.: The initial stages of blood coagulation. J. Physiolog. 122, 538 (1953).

    Google Scholar 

  20. Biggs, R., Douglas, A. S.: The thromboplastin generation test. J. Clin. Pathol. 6, 23 (1953).

    Google Scholar 

  21. Biggs, R., Macfarlane, R. G.: Human blood coagulation and its disorders. Blackwell, Oxford 1953.

    Google Scholar 

  22. Brinkhous, K. M.: Clotting defect in hemophilia, Deficiency in a plasma factor required for platelet utilisation. Proc. Soc. Exp. Biol. & Med. 66, 117 (1947).

    Google Scholar 

  23. Brinkhous, K. M., Graham, J. B.: Hemophilia and the Hemophiloid states. Blood 9, 254 (1954).

    Google Scholar 

  24. Brinkhous, K. M., Langdell, R. D., Penick, G. D., Graham, J. B., Wagner, R. H.: Newer approaches to the study of hemophilia and the hemophiloid states. J. Amer. Med. Ass. im Druck, zit. nach 23).

  25. Brink, A. J., Kingsley, L. S.: A familial disorder of blood coagulation due to deficiency of the labile factor. Quart. J. Med. N. S. 21, 19 (1951).

    Google Scholar 

  26. Caussade, L., Neuman, N., Pierson, M., Manciaux, M.: L'Afibrinogénémie congénitale et familiale. (A propos de trois observations). Press. Méd. 1040–1042 (1954).

  27. Collins, I. S.: Haemophilia-like disease produced by a circulating anticoagulant. Austral. Ann. Med. 2, 161–169 (1953).

    Google Scholar 

  28. Cramer, P., Flückinger, P., Gasser, L., Koller, F., Loelinger, A., Matter, M.: L'Hemophilia B. Acta Hematolog. 10, 65 (1953).

    Google Scholar 

  29. Cramer, P., Matter, M., Loelinger, A.: Die Hämophilie B. Zwei familiäre Fälle der Bluterkrankheit bedingt durch den Mangel eines neuen Gerinnungsfaktors (≫Christmas-Faktor≪). Helv. Ped. Act. 8, 185 (1953).

    Google Scholar 

  30. van Crefeld, S., Paulssen, M. M. P.: Haemorrhagic diathesis due to absence of Christmas factor. Lancet 264, 823 (1953).

    Google Scholar 

  31. Deutsch, E.: Die hämophilie-ähnlichen hämorrhagischen Diathesen. Erg. Inn. Med. u. Kinderhk. N. F., V., 553–641 (1954).

    Google Scholar 

  32. Deutsch, E.: Blutgerinnungsfaktoren. Einzeldarstellungen aus dem Gesamtgebiet der Biochemie, Neue Folge, Bd. 1, Deuticke, Wien 1955.

    Google Scholar 

  33. Duckert, F., Flückinger, P., Isenschmid, H., Matter, M., VogelMeng, J., Koller, F.: A modification of the thromboplastin generation test. Acta haematolog. 12, 197 (1954).

    Google Scholar 

  34. Fantl, P., Sawers, R. J.: B prothromboplastin deficiency causing a hemorrhagic tendency resembling hemophilia. Med. J. Australia 1, 925–928 (1954).

    Google Scholar 

  35. Fantl, B., Margolis, J.: Alpha-prothromplastin deficiencies (Haemophilia) of different degrees in a mother and son. Brit. Med. J. 640–642 (1955).

  36. Flückinger, P., Duckert, F., Koller, F.: Die Bedeutung des Faktor X für die Antikoagulantientherapie. Schweiz. Med, Wschr., 84, 1127–1128 (1954).

    Google Scholar 

  37. Flynn, J. E. (Editor): Blood clotting and allied problems. Macy foundation, New York 1952.

    Google Scholar 

  38. Gerhard, Walther: A new form of hereditary thrombopathia. Z. inn. Med. 8, 221–227 (1953).

    Google Scholar 

  39. Graham, J. B., Penick, G. D., Brinkhous, K. M.: Utilization of the antihemophilic factor during clotting of canine blood and plasma. Amer. J. Physiol. 164, 710 (1951).

    Google Scholar 

  40. Graham, J. B., Collins, D-L-jr., Godwin, I. D., Brinkhous, K. M.: Assay of plasma antihemophilic activity in normal, heterozygous (hemophilia) and prothrombinopenic dogs. Proc. Soc. Exper. Biol. & Med. 77, 294 (1951).

    Google Scholar 

  41. Graham, J. B., Brinkhous, K. M.: Christmas disease. Brit. M. J. 2, 97 (1953).

    Google Scholar 

  42. Graham, J. B., McLendon, W. W., Brinkhous, K. M.: Mild hemophilia: an allelic form of the disease. Am. J. Med. Sc. 225, 46 (1953).

    Google Scholar 

  43. Hagen, P. S., Watson, L. J.: Idiopathic (familial) hypoprothrombinemia. J. Lab. & Clin. Med. 33, 542 (1948).

    Google Scholar 

  44. Heni, F., Krauss, I.: Angeborener Faktor V-Mangel (Owren'sche Krankheit). Klin. Wschr. S. 633–635 (1954).

  45. Hill, J. M., Crass, G., Ellis, J., Wittstruck, K. P.: Studies on the inheritance of hemophilia by laboratory tests. Tex. J. Med. 49, 241 (1953).

    Google Scholar 

  46. Hill, J. M., Speer, R. L.: Combined hemophilia and PTC-deficiency. Blood 10, 357–361 (1955).

    Google Scholar 

  47. Hinsworth, Sir.: Haemophilia, Brit. Med. J. 2, 1287 (1954).

    Google Scholar 

  48. Israels, M. C. G., Lempert, H., Gilbertson, E.: Haemophilia in the female. Lancet S. 1375 (1954).

  49. Johnson, S. A.: Activation of purified prothrombin with hemophilic plasma. Am. J. Clin. Path. 23, 875 (1953).

    Google Scholar 

  50. Joules, H., Macfarlane, R. G.: Pseudo-hemophilia in a women. Lancet 1, S. 715 (1938).

    Google Scholar 

  51. Kingsley, L. S.: Familial factor V deficiency: the pattern of heredity. Quart J. Med. N. S. 23, 323–329 (1954).

    Google Scholar 

  52. Koller, F., Krüsi, G., Luchsinger, P.: Über eine besondere Form hämorrhagischer Diathese. Schweiz. Med. Wschr. 80, 1101 (1950).

    Google Scholar 

  53. Koller, F.: Die Physiologie der Blutgerinnung, ihre Bedeutung für die Klinik. Arch. exp. Pathol. u. Pharmakol. 222, 89–106 (1954).

    Google Scholar 

  54. Koller, F.: Blood IX, 286 (1954).

    Google Scholar 

  55. Langdell, R. D., Wagner, R. H., Brinkhous, K. M.: Effect of antihemophilic factor on one-stage clotting tests. J.-Lab. & Clin. Med. 41, 637 (1953).

    Google Scholar 

  56. Lawson, H. A.: Congenital afibrinogenemia. New Engl. J. Med. 248, 552 (1953).

    Google Scholar 

  57. Lewis, J. H., Ferguson, J. H.: Hypoproaccelerinemia. Blood X, 351–356 (1955).

    Google Scholar 

  58. Lewis, J. H., Ferguson, J. N.: Hemorrhagic diathesis due to PTC (Plasma thromboplastin component) deficiency. Proc Soc. Exp. Biol. & Med. 82, 445 (1953).

    Google Scholar 

  59. Lewis, M. L., Ware, A. G.: The mechanism of action of human accelerator globulin and its relation to other clotting factors. Blood 9, 520–530 (1954).

    Google Scholar 

  60. Macfarlane, R. G., Biggs, R., Bidwell, E.: Bovine antihaemophilic globulin in the treatment of haemophilia. Lancet 1, 1316–1319 (1954).

    Google Scholar 

  61. Macfarlane, R. G.: Hemophilia, Christmas disease, and matters of terminology. Blood 9, 258 (1954).

    Google Scholar 

  62. Macfarlane, R. G., Biggs, R.: Thromboplastin generation with particular reference to hemophilia. Sang 26, 180 (1955).

    Google Scholar 

  63. McMillan, R. L., Brown, K. W. G.: Christmas disease-a variant of hemophilia. Canad. Med. Ass. J. 69, 623 (1953).

    Google Scholar 

  64. Merksey, C.: Hemophilia associated with a normal coagulation time. Brit. Med. J. 1, 906 (1951).

    Google Scholar 

  65. Merksey, C., Macfarlane, R. G.: The female carrier of haemophilia. Lancet 1, 487 (1951).

    Google Scholar 

  66. Merskey, C.: The occurrence of hemophilia in the human female. Quart. J. Med. 20, 299 (1951).

    Google Scholar 

  67. Owren, P. A.: Parahemophilia. Lancet 1, 446 (1947).

    Google Scholar 

  68. Owren, P. A.: Prothrombin and accessory factors. Am. J. Med. 14, 201 (1953).

    Google Scholar 

  69. Pawlowsky, A.: Contribution to the pathogenesis of hemophilia. Blood 2, 185 (1947).

    Google Scholar 

  70. Pavlovsky, A., Mittelmann, D. G. de, Castellanos, H.: Intetaccion de plasmas de distintos hemophilicos. Reunion anual del instituto de investigaciones ficicas aplicadas, a la Patologia humana, Academia nacional de Medicina, Buenos Aires, Dec 1950.

    Google Scholar 

  71. Pavlovsky, A.: Present concepts of hemophilia. Blood 9, 291 (1954).

    Google Scholar 

  72. Pavlovsky, A., Bergna, L. J., Canaveri, A. A. M.: Thromboplastin in hemophilia. Sang 26, 181 (1955).

    Google Scholar 

  73. Pitney, W. R., Dacie, J. V.: Haemophilia and allied disorders of blood coagulation. Brit. Med. Bull. 11, 11–16 (1955).

    Google Scholar 

  74. Poole, J. C. F.: A hemorrhagic state resembling hemophilia. Lancet 1, 122 (1953).

    Google Scholar 

  75. Quick, A. J.: Congenital familial hypoprothrombinemias. J. Lab. & Clin. Med. 32, 1424 (1947).

    Google Scholar 

  76. Quick, A. J.: Congenital hyprothrombinemia and pseudo-hypoprothrombinemia. Lancet 2, 379 (1947).

    Google Scholar 

  77. Quick, A. J.: Studies on the enigma of the hemostatic dysfunction of hemophilia. Am. J. Med. Sc. 214, 272 (1947).

    Google Scholar 

  78. Quick, A. J.: The physiology and pathology of hemostasis. Lea & Fiebinger, Philadelphia 1951.

    Google Scholar 

  79. Quick, A. J., Hussey, C. V.: Haemophilia: Clinical and laboratory observations relative to diagnosis and inheritance. Am. J. Med. Sc. 223, 401 (1952).

    Google Scholar 

  80. Quick, A. J., Hussey, C. V., Stapp, W. F.: The effect of heating on the thromboplastic acticity of rabbit brain extract, a new test for the diagnosis of hemophilia. J. Lab. & Clin. Med. 39, 142 (1952).

    Google Scholar 

  81. Quick, A. J.: Haemophilia. Am. J. Med. 14, 349 (1953).

    Google Scholar 

  82. Quick, A. J.: The pathological physiology of hemorrhagic conditions. Bull. New York Acad. Med. 29, 226 (1953).

    Google Scholar 

  83. Quick, A. J.: On the nature and diagnosis of hemophilia. Blood 9, 265 (1954).

    Google Scholar 

  84. Ratnoff, O., Colopy, J. E.: A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma. J. Clin. Invest. 34, 602–613 (1955).

    Google Scholar 

  85. Rosenthal, R. L., Dreskin, O. H., Rosenthal, N.: New hemophilia-like disease caused by deficiency of a third thromboplastin factor. Proc. Soc. Eexp. Biol. & Med. 82, 171 (1953).

    Google Scholar 

  86. Rosenthal, R. L.: Hemophilia and Hemophilia-like disease caused by deficiencies in plasma thromboplastin factors: Am. J. Med. 17, 57 (1954).

    Google Scholar 

  87. Rosenthal, R. L.: Plasma thromboplastin antecedent (PTA): Properties and role in the clotting mechanism. Fed. Proc. 13, 284 (1954).

    Google Scholar 

  88. Rosenthal, M. L., Sanders, M.: Plasma thromboplastin component deficiency I. Studies on its inheritance and treatment. Am. J. Med. 16, 153 (1954).

    Google Scholar 

  89. Rosenthal, R. L., Dreskin, O. H., Rosenthal, N.: Plasma thromboplastin antecedent (PTA) deficiency: Clinical Coagulation, therapeutic and hereditary aspects of a new hemophilia-like disease. Blood 10, 120–131 (1955).

    Google Scholar 

  90. Schulman, I., Smith, L. H.: Hemorrhagic disease in an infant due to deficiency of a previously undescribed clotting factor. Blood 7, 798 (1952).

    Google Scholar 

  91. Spaet, T. H., Kinsell, B., Behring, H. M., Aggeler, P. M.: A typical blood clotting patterns in hemophilia. Stanford Med. Bull. 11, 118 (1953).

    Google Scholar 

  92. Spaet, T. H., Kinsell, B. G.: Properties of bovine antihemophilic factor. Proc. Soc. Exp. Biol. & Med. 84, 314 (1953).

    Google Scholar 

  93. Speer, R. J., Hill, J. M., Maloney, M., Roberts, A.: Hemorrhagic diathesis associated with hyperheparinemia. J. Lab. Clin. Med. 45, 730–739 (1955).

    Google Scholar 

  94. Stefanini, M.: Hemophilia: Specific entity or syndrome? Blood 9, 273 (1954).

    Google Scholar 

  95. Soulier, J. P., Larrieu, M. J.: Measurement of thromboplastic factors and profactors in Plasma. I. Deficits in Thromboplastin. J. Lab. & Clin. Med. 41, 849–864 (1953).

    Google Scholar 

  96. Soulier, J. P., Larrieu, M. J.: Differentiation of hemophilia into two groups. A study of thirty-three cases. New England J. Med. 249, 547–553 (1953).

    Google Scholar 

  97. Soulier, J. P., Larrieu, M. J.: Nouvelle methode de diagnostic des facteurs de l'hemophilie. Dosages des facteurs antihémophiliques A et B. Sang 24, 205 (1953).

    Google Scholar 

  98. Soulier, J. P., Larrieu, M. J., Wartelle, O.: Modification des facteurs de coagulation dans le plasma et le sang conservé. Sem. d'Hop. Paris 54–55, 3117–3130 (1954).

    Google Scholar 

  99. Soulier, P. J., Larrieu, M. J.: Etude de la correction in vitro de l'hémophilie (A et B) par différentes dilutions de plasma normal., Sem. d'Hop. Paris 30, No. 52–53 (1955).

    Google Scholar 

  100. Soulier, J. P., Larrieu, M. J.: Diatesi hemorrhagiche costitutionali con allungamento del tempo di emorragia senza piastunopenia. (Studio di 65 casi). Hematologica (Pavia) 39, 1–22 (1955).

    Google Scholar 

  101. Tocantins, L. M., Caroll, R. T.: Activity curves of crude and purified inhibitors and accelerators of blood coagulation. Proc. Soc. Exp. Biol. & Med. 69, 431 (1948)

    Google Scholar 

  102. Tocantins, L. M., Carrol, R. T.: Coagulation decelerating action of hemophilic plasma on normal plasma. Fed. Proc. 8, 157 (1949).

    Google Scholar 

  103. Tocantins, L. M., Carrol, R. T.: Peparation and assay of a lipid antithromboplastin from human brain, plasma and plasma fractions. In: Trans: II. Macy Found. Conf. on Blood clotting and allied problems. Vol. II, S. 11, 1949.

  104. Tocantins, L. M., Carrol, R. T.: Distribution and assay of inhibitors and accelerators of blood coagulation in extracts of organs of a normal and a hemophilic man. Fed. Proc. 9, 127 (1950).

    Google Scholar 

  105. Tocantins, L. M., Holburn, R. R., Carrol, R. T.: Clot accelerating activity of euglobulin fractions from normal and hemophilic plasmas. Fed. Proc. 10, 137 (1951).

    Google Scholar 

  106. Tocantins, L. M., Holburn, R. R., Carrol, R. T.: Nature of coagulation defect in hemophilic blood. Trans. IV. Macy Jr. Found Conf. on Blood clotting and allied problems. IV, S. 89 (1951).

    Google Scholar 

  107. Tocantins, L. M.: Hemophilic syndromes and hemophilia. Blood 9, 281 (1954).

    Google Scholar 

  108. de Vries, A., Matoth, M., Shamir, Z.: Familial congenital labile factor deficiency with syndactylism. Acta haematolog. 5, 130 (1951).

    Google Scholar 

  109. Vogel, F.: Vergleichende Betrachtungen über die Mutationsrate der geschlechtsgebundenrezessiven Hämophilieformen in Dänemark und der Schweiz. Blut 1, 91 (1955).

    Google Scholar 

  110. White, S. G., Aggeler, P. M., Glendening, M. B., Page, E. P., Leake, T. B., Bates, G.: PTC factor: a new plasma thromboplastin component distinct from the anti-hemophilic factor. J. Clin. Invest. 31, 673 (1952).

    Google Scholar 

  111. White, S. G., Aggeler, P. M., Glendening, M. B.: Plasma thromboplastin component (PTC). A hitherto unrecognized blood coagulation factor. Case-report of PTC-deficiency. Blood 8, 101 (1953).

    Google Scholar 

  112. White, S. G., Aggeler, P. M., Glendening, M. B.: Plasma thromboplastin component (PTC) potency of plasma fractions. Proc. Soc. Exper. Biol. & Med. 83, 69 (1953).

    Google Scholar 

  113. Wiener, A. S.: Christmas disease. Brit. Med. J. 1, 559 (1953).

    Google Scholar 

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    Friedrich Vogel

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Vogel, F. Neue Ergebnisse der Hämophilie-Forschung. Blut 1, 214–222 (1955). https://doi.org/10.1007/BF01630086

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