Summary
The effect of a tumour angiogenesis factor on proliferation of various kinds of cells was examined in vitro. The factor (TAF) a polypeptide of 14000 molecular weight, was extracted and purified from the conditioned medium of ovarian clear cell carcinoma cell line (HUOCA-II). TAF at concentrations of 10 ng/ml and 100 ng/ml promoted proliferation of the endothelial cells and induced tube formation. However, it had no stimulatory effect on the proliferation of fibroblasts, endometrial columnar cells, squamous epithelial cells or cancer cells.
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Ishiwata, I., Ishiwata, C., Soma, M. et al. Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation. Vichows Archiv A Pathol Anat 417, 473–476 (1990). https://doi.org/10.1007/BF01625726
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DOI: https://doi.org/10.1007/BF01625726