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Beeinflussung der fäkalen Gallensäureexkretion durch Fischöl bei gesunden Probanden

Effects of fish oil on fecal bile acid excretion in healthy volunteers

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Zusammenfassung

Verschiedene Studien weisen auf einen protektiven Effekt von Fischöl bei der Kolonkarzinomentstehung hin. Mögliche Einflüsse auf die muscosale Prostaglandin-E2-Synthese wurden hierbei als Wirkungsmechanismus beschrieben. Zusätzliche Effekte auf die fäkale Exkretion von Gallensäuren könnten ebenso von Bedeutung sein, da insbesondere sekundäre Gallensäuren als Promotoren bei der Kolontumorentstehung angesehen werden. In der vorliegenden Studie wurde bei 12 gesunden Probanden der Effekt einer täglichen Supplementierung mit 11 g Fischöl (FO) bzw. Maiskeimöl (MO) über jeweils 4 Wochen zusätzlich zu einer fettreduzierten Basiskost (30 % der Gesamtenergie als Fett) auf die fäkale Exkretion von Gallensäuren untersucht. Die Analyse des fäkalen Gallensäurenspektrums erfolgte gaschromatographisch. Die Gesamtausscheidung an Gallensäuren war unter FO nicht signifikant verschieden von derjenigen unter MO (301,9 vs. 320,3 mg/Tag). Unter FO ergab sich jedoch eine tendenziell niedrigere Exkretion der sekundären Gallensäure Lithocholsäure als unter MO (99,6 vs. 109,4 mg/Tag, p=0,22). Da sekundäre Gallensäuren als ein wesentlicher Promotor der Kolonkarzinogenese angesehen werden, sind diese Veränderungen positiv im Hinblick auf eine mögliche Kolonkarzinomprävention zu werten.

Summary

Several studies indicated a protective effect of fish oil on colon carcionogenesis which might be due to alterations in prostaglandin E2 synthesis of the colonic mucosa. Additional effects on fecal bile acid excretion may also play a role since especially secondary bile acids are known to act as promotors in colon cancer development. In the present study possible influences on bile acid excretion were investigated in 12 healthy volunteers whose daily diet was supplemented for 4 weeks with 11 g of fish oil (FO) and corn oil (CO) per day, respectively. Fecal bile acids were analyzed by gas-liquid-chromatography. Fecal excretion of total bile acids was not different during the periods of FO and CO-supplementation (301.9 vs. 320.3 mg/day). However, a non-significant trend to a lower daily excretion of the secondary bile acid lithocholic acid was found after FO compared to CO-ingestion (99.6 vs. 109.4 mg/day; p=0.22). Since secondary bile acids are known promotors of colon carcinogenesis, these findings may implicate a favorable situation with respect to colon cancer prevention.

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Authors and Affiliations

  1. Medizinische Universitätsklinik, Josef-Schneider-Straße 2, 97080, Würzburg

    H. -P. Bartram, A. Gostner, W. Scheppach, E. Kelber, G. Dusel, F. Keller & H. Kasper

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  1. H. -P. Bartram
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  2. A. Gostner
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  3. W. Scheppach
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  4. E. Kelber
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  5. G. Dusel
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  6. F. Keller
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  7. H. Kasper
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Additional information

Diese Studie wurde finanziert vom Bundesministerium für Forschung und Technologie (Projekt 07ERG09/2). Den Kneipp-Werken, Würzburg, wird gedankt für die Bereitstellung der Fischöl- und Maiskeimölkapseln.

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Bartram, H.P., Gostner, A., Scheppach, W. et al. Beeinflussung der fäkalen Gallensäureexkretion durch Fischöl bei gesunden Probanden. Z Ernährungswiss 34, 231–235 (1995). https://doi.org/10.1007/BF01623163

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  • DOI: https://doi.org/10.1007/BF01623163

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