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Hepatic lipid peroxidation and trace elements — nutritional status in streptozotocin-induced diabetic rats

Lipidperoxidation in der Leber und Ernährungsstatus von Spurenelementen bei Ratten mit Streptozotocin-induziertem Diabetes

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Summary

The aim of this experiment was to study the interrelationships between nutritional status of chosen trace elements (Cu, Zn, Fe) and hepatic lipid peroxidation in streptozotocin-induced diabetic rats. Both copper accumulation and disruption of iron storage were observed in livers of diabetic rats. MDA 0' (baseline) and MDA 30' (produced) levels measured in the liver were negatively correlated with blood glucose levels. MDA 30' levels correlated positively with iron concentration in the liver. It is supposed that the hormonal lability during experimental diabetes caused changes in metabolism of trace elements, and subsequently influenced the rate of lipid peroxidation.

Zusammenfassung

Diese Arbeit hatte eine Überprüfung der gegenseitigen Abhängigkeit des Ernährungsstatus von ausgewählten Spurenelementen (Cu, Zn, Fe) und der Lipidperoxidation in der Leber von Ratten mit Streptozotocin-induziertem Diabetes vor. Es wurde eine Akkumulation des Cu in Leber und eine Speicherstörung des Fe bei Diabetes-Ratten beobachtet. Der MDA-0'-Spiegel wie auch der MDAS-30'-Spiegel korrelierten statistisch bedeutsam mit dem Zuckerspiegel des Blutes. MDA 30' korrelierte positiv mit dem Fe-Spiegel in der Leber. Man kann annehmen, daß die — während des experimentell hervorgerufenen Diabetes — hormonale Labilität Änderungen im Stoffwechsel der Spurenelemente verursachte, was in der Folge einen Einfluß auf die Intensivität der Lipidperoxidation ausübte.

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Abbreviations

(MDA):

Malondialdehyde

(bm):

Body mass

(Tg):

Triglyceride

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Authors and Affiliations

  1. National Institute of Food-Hygiene and Nutrition, Budapest, Hungary

    A. Wachnik, G. Biró, L. Biró, A. Gergely & M. Antal

  2. National Research Institute of Mother and Child, Warsaw, Poland

    A. Wachnik

Authors
  1. A. Wachnik
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  2. G. Biró
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  3. L. Biró
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  4. A. Gergely
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  5. M. Antal
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Wachnik, A., Biró, G., Biró, L. et al. Hepatic lipid peroxidation and trace elements — nutritional status in streptozotocin-induced diabetic rats. Z Ernährungswiss 31, 103–109 (1992). https://doi.org/10.1007/BF01623068

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  • DOI: https://doi.org/10.1007/BF01623068

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