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Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo

  • Session VI: Pathogenesis: Cytokines And Immunity
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References

  1. Kurihara N, Suda T, Miura Y, Nakasuchi H, Kodama H, Hiura K, et al. Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 1989;74:1295–302.

    Google Scholar 

  2. Kahn AJ, Simmons DJ. Investigation of the cell lineage in bone using a chimera of chick and quail embryonic tissue. Nature 1975;258:325–7.

    Google Scholar 

  3. Schevan BAA, Visser JWM, Nijweide PJ.In-vitroosteoclast generation form different bone marrow fractions, including a highly enriched hematopoietic stem cell population. nature 1986;321:79–81.

    Google Scholar 

  4. Kurihara N, Civin C, Roodman GD. Osteoporotic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype. J Bone Miner Res 1991;6:257–61.

    Google Scholar 

  5. Hattersley G, Kerby JA, Chambers TJ. Indentification of osteoclast precursors in multilineage hematopoietic colonies. Endocrinology 1991;128:259–62.

    Google Scholar 

  6. Owen M. Lineage of osteogenic cells and their relationship to the stromal system. J Bone Miner Res 1985;3:1–24.

    Google Scholar 

  7. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, et al. Osteoblastic cells are involved in osteoclast formation. Endocrinology 1988;123:2600–2.

    Google Scholar 

  8. McSheehy PMJ, Chambers TJ. Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 1986;118:824–8.

    Google Scholar 

  9. McSheehy PJM, Chambers TJ. 1,25-dihydroxyvitamin D3 stimualtes rate osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J Clin Invest 1987;80:425–9.

    Google Scholar 

  10. Udagawa N, Takahishi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, et al. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989;125:1805–13.

    Google Scholar 

  11. Hattersley G, Chambers TJ. Generation of osteoclsts from hematopoietic cells and a multipotential cell line in-vitro. J Cell Physiol 1989;140:478–82.

    Google Scholar 

  12. Harowitz MC, Einhorn TA, Philbrick W, Jilka RL. Functional and molecular changes in colony stimulating factor secretion by osteoblasts. J Connective Tissue Res 1989;20:159–68.

    Google Scholar 

  13. MacDonald BR, Mundy GR, Clark S, Wang EA, Kuehl TJ, Stanley ER, et al. Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures. J Bone Miner Res 1986;1:227–33.

    Google Scholar 

  14. Hattersley G, Chambers TJ. Effects of interleukin-3 and of granulocyte-macrophage and macrophage colony stimulating factors on osteoclast differentiation from mouse hematopoietic tissue. J Cell Physiol 1990;142:201–9.

    Google Scholar 

  15. Thomson BM, Saklatvala J, Chamber TJ. Osteoblasts mediate interleukin 1 stimulation of bone resorption by rate osteoclasts. J Exp Med 1986;164:104–12.

    Google Scholar 

  16. Thomson BM, Mundy GR, Chambers TJ. Tumor necrosis factors a and b induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunol 1987;138:775–9.

    Google Scholar 

  17. Kishimoto T. The biology of interleukin-6. Blood 1989;74:1–10.

    Google Scholar 

  18. Wong GG, Witek JAS, Temple PA, Kritz R, Ferenz C, Hewick RM, et al. Stimulation of murine hematopoietic colony formation by human interleukin-6. K Immunol 1988;140:3040–4.

    Google Scholar 

  19. Lowik CWGM, van der Pluijm G, Bloys H, Hoeckman K, Bijvoet OLM, Aarden LA, et al. Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Commun 1989;162:1546–52.

    Google Scholar 

  20. Ishimi Y, Miyaura C, He Jin C, Akatsu T, Abe E, Nakamura Y, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990;145:3297–303.

    Google Scholar 

  21. Black K, Garrett IR, Mundy GB. Chinese hamster ovarian cells tranfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 1991;128:2657–59.

    Google Scholar 

  22. Feyen JHM, Elford P, DiPadova FE, Trechsel U. Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 1989;4:633–8.

    Google Scholar 

  23. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, et al. 17-Estradiol inhibits interleukin-6 production by bone marrow stromal cells and osteoblast in vitro: a potential mechanism for the antiosteoporitic effect of estrogens. J Clin Invest 1991 (in press).

  24. Bellido T, Girasole G, Passeri G, Yu XP, Jilka RL, Boder G, et al. Demonstration of estrogen receptors by Western blot analysis in bone marrow stromal cells and osteoblasts: correlation with interleukin-6 registration by estrogens and anti-estrogens [abstracts]. J Bone Miner Res 1991;6[supplement 1]:88.

    Google Scholar 

  25. Turner RT, Wakey JK, Hannon KS, Bell NH. Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats. Endocrinology 1988;122:1146–50.

    Google Scholar 

  26. Passeri G, Girosole G, Markus T, Abrams JS, Manolagas SC, Jilka RL. 17β-Estradiol regulators IL-6 production and osteclast development in murine calvaria cell cultures [abstract]. J Bone Miner Res 1991;6[supplement 1]: 263.

    Google Scholar 

  27. Passeri G, Girasole G, Manolagas SC, Jilka RL. Estrogen withdrawal in-vitro or in-vivo augments interleukin-6 production by bone marrow cells in response to resorbing agents. In: Proceedings of the XIth international conference on calcium regulating hormones (in press).

  28. Jilka RL, Girasole G, Passeri G, Williams D, Abrams J, Manolagas SC. Interleukin-6 neutralizing antibody administration prevents osteoclastogenic response to ovariectomy in the mouse. In: Proceedings of the XIth international conference on calcium regulating hormones (in press).

  29. Girasole G, Passeri G, Jilka RL, Manolagas SC. Increase in bone marrow progenitors accounts for osteoclastogenic response to ovariectomy in the mouse. In: Proceedings of the XIth international conference on calcium regulating hormones (in press).

  30. Riggs BL, Melton LJ. Involutional osteoporosis. N Engl J Med 1986;314:1676.

    Google Scholar 

  31. Riggs BL, Jowsey J, Kelly PJ, Jones JD, Maher FT. Effect of sex hormones on bone primary osteoporosis. J Clin Invest 1969;48:1065–72.

    Google Scholar 

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Authors and Affiliations

  1. Section of Endocrinology and Metabolism, VA Medical Center, Indianapolis, Indiana, USA

    S. C. Manolagas, R. L. Jilka, G. Girasole, G. Passed & T. Bellido

  2. Departments of Medicine and Biochemistry, Indiana University Medical School, Indianapolis, Indiana, USA

    S. C. Manolagas, R. L. Jilka, G. Girasole, G. Passed & T. Bellido

Authors
  1. S. C. Manolagas
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  2. R. L. Jilka
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  3. G. Girasole
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  4. G. Passed
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  5. T. Bellido
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Manolagas, S.C., Jilka, R.L., Girasole, G. et al. Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo. Osteoporosis Int 3 (Suppl 1), 114–116 (1993). https://doi.org/10.1007/BF01621882

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  • DOI: https://doi.org/10.1007/BF01621882

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