References
Elford PR, Felix R, Cecchini M, Trechsel U, Fleisch H. Murine osteoblast-like cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in culture. Calcif Tissue Int 1987;41:151–6.
Felix R, Fleisch H, Elford P. Bone-resorbing cytokines enhance release of macrophage colony-stimulating activity by the osteoblastic cell MC3T3-E1. Calcif Tissue Int 1989;44:356–60.
Sato K, Fujii Y, Asano S et al. Recombinant human interleukin 1 alpha and beta stimulate mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2. Biochem Biophys Res Comm 1986;141:285–91.
Sato K, Kasono K, Fujii Y, Kawakami M, Tsushima T, Shizume K. Tumor necrosis factor type alpha (cachectin) stimulates mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2. Biochem Biophys Res Comm 1987;145:323–9.
Shiina-Ishimi Y, Abe E, Tanake H, Suda T. Synthesis of colony-stimulating factor (CSF) and differentiation-induced factor (D-factor) by osteoblastic cells, clone MC3T3-E1. Biochem Biophys Res Comm 1986;134:400–6.
Hofstetter W, Wetterwald A, Cecchini M, Felix R, Mueller C, Fleisch H. Expression of M-CSF and of its receptor, C-FMS, in bone, as detected by in situ hybridization. J Bone Miner Res 1991;611:S199
MacDonald BR, Mundy GR, Clark S, et al. Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures. J Bone Miner Res 1986;1:227–33.
Kurihara N, Suda T, Miura Y, et al. Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 1989;74:1295–302.
Shinar DM, Sato M, Rodan GA. The effect of hemopoietic growth factors on the generation of osteoclast-like cells in mouse bone marrow cultures. Endocrinology 1990;126:1728–35.
van de Wijngaert FP, Tas MC, van der Meer JWM, Burger EH. Growth of osteoclast precursor-like cells from whole mouse bone marrow: inhibitory effect of CSF-1. Bone Miner 1987;3:97–110.
Hattersley G, Chambers TJ. Effects of interleukin 3 and of granulocyte-macrophage and macrophage colony stimulating factors on osteoclast differentiation from mouse hemopoietic tissue. J Cell Physiol 1990;142:201–9.
Hattersley G, Dorey E, Horton MA, Chambers TJ. Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone. J Cell Physiol 1988;137:199–203.
Burger EH, van de Meer JWM, van de Grevel JS, Cribnau JC, Thesingh CW, van Furth R. In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes. J Exp Med 1982;156:1604–14.
Hagenaars CE, van der Kraan AAM, Kawilarang-de Haas EWM, Visser JWM, Nijweide PJ. Osteoclast formation from cloned pluripotent hemopoietic stem cells. Bone Miner 1989;6:179–89.
Antonioli Corboz V, Cecchini MG, Felix R, Fleisch H, van der Pluijm G, Löwik CWGM. Effect of macrophage colony-stimulating factor on in vivo osteoclast generation and bone resorption. Endocrinology (in press).
Lorenzo JA, Sousa SL, Fonseca JM, Hock JM, Medlock ES. Colony-stimulating factors regulate the development of multinucleated osteoclasts from recently replicated cells in vitro. J Clin Invest 1987;80:160–4.
Löwikl CWGM, van der Pluijm G, Bloys H, et al. Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem Biophy Res Comm 1989;162:1546–52.
Marks SC, Lane PW. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse. J Hered 1976;67:11–18.
Wiktor-Jedrzejczak W, Ahmed A, Szczylik C, Skelly RR. Hematological characterization of congenital osteopetrosis inop/op mouse. J Exp Med 1982;156:1516–27.
Felix R, Hofstetter W, Stutzer A, Fleisch H. Impairment of macrophage colony-stimulating factor (M-CSF) production in the osteopetroticop/op mouse. J Bone Miner Res 1988;3:S134.
Felix R, Cecchini MG, Hofstetter W, Elford PR, Stutzer A, Fleisch H. Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophage in the osteopetroticop/op mouse. J Bone Miner Res 1990;5:781–9.
Wiktor-Jedrzejczak W, Bartocci A, Ferrante Jr AW, et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 1990;87:4828–32.
Yoshida H, Hayashi S-I, Kunisada T, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990;345:442–4.
Naito M, Hayashi S-I, Yoshida H, Nishikawa S-I, Shultz LD, Takahashi K. Abnormal differentiation of tissue macrophage populations in ‘osteopetrosis’(op) mice defective in the production of macrophage colony-stimulating factor. Amm J Pathol 1991;139:657–67.
Cecchini MG, Felix R, Hofstetter W, et al. Tissue distribution of resident macrophages (rMø) in the macrophage colony-stimulating factor (M-CSF) deficientop/op mouse. In: Fourth workshop on cell cytokines, Davos, 1992 (submitted).
Takahashi N, Udagawa N, Akatsu T, Tanaka H, Isogai Y, Suda T. Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology 1991;128:1792–6.
Felix R, Cecchini MG, Fleisch H. Macrophage colony stimulating factor restores in vivo bone resorption in theop/op osteopetrotic mouse. Endocrinology 1990;127:2592–4.
Kodama H, Yamasaki A, Nose M, et al. Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med 1991;173:269–72.
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Fleisch, H., Hofstetter, W., Felix, R. et al. The role of macrophage stimulating factor M-CSF in bone resorption. Osteoporosis Int 3 (Suppl 1), 108–110 (1993). https://doi.org/10.1007/BF01621880
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DOI: https://doi.org/10.1007/BF01621880