Skip to main content

Absorption characteristics of human fetal hemoglobin at wavelengths used in pulse oximetry

Abstract

The absorption characteristics of fetal and adult human hemoglobin samples were determined for the range of 600 to 1,050 nm. Over this range, fetal hemoglobin absorption is nearly identical to that of adult hemoglobin. Since currently available two-wavelength pulse oximeters base their calculations of arterial oxyhemoglobin saturation on absorption at the wavelengths of 660 and 920 nm, we conclude that the accuracy of two-wavelength pulse oximetry previously demonstrated in adults can be extrapolated to infants with high concentrations of fetal hemoglobin.

This is a preview of subscription content, access via your institution.

References

  1. Deckhardt R, Steward DJ. Noninvasive arterial hemoglobin oxygen saturation versus transcutaneous oxygen tension monitoring in the preterm infant. Crit Care Med 1984;12:935–939

    Google Scholar 

  2. Jennis MS, Peabody JL. No burns, no gradient—pulse oximetry, an alternative to transcutaneousPO 2. Pediatr Res 1985;19:142A

    Google Scholar 

  3. Durando M, Ramanathan R. Pulse oximetry for continuous oxygen monitoring in sick newborn infants. J Pediatr 1986;109:1052–1056

    Google Scholar 

  4. Sendak MJ, Harris AP, Donham RT. Accuracy of pulse oximetry during severe arterial oxyhemoglobin desaturation in dogs. Anesthesiology 1988;68:111–114

    Google Scholar 

  5. van Assendelft OW. Spectrophotometry of haemoglobin derivatives. Springfield, IL: Thomas, 1970:8–73

    Google Scholar 

  6. Comelissen PJH, van Woensel CLM, van Oel WC, deJong PA. Correction factors for hemoglobin derivatives in fetal blood, as measured with the IL 282 CO-Oximeter. Clin Chem 1983;29:1555 (Letter)

    Google Scholar 

  7. Ryan CA, Barrington KH, Vaughan D, Finer NN. Directly measured arterial oxygen saturation in the newborn infant. J Pediatr 1986;109:526–529

    Google Scholar 

  8. Zijlstra WG, Buursma A, Koek J, Zwart A. Correction factors for hemoglobin derivatives in fetal blood, as measured with the IL 282 CO-Oximeter. Clin Chem 1983;29:1556 (Reply)

    Google Scholar 

  9. Bunn HF, Forget BG, Ranney HM. Human hemoglobins. Philadelphia: Saunders, 1977:1–4

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Harris, A.P., Sendak, M.J., Donham, R.T. et al. Absorption characteristics of human fetal hemoglobin at wavelengths used in pulse oximetry. J Clin Monitor Comput 4, 175–177 (1988). https://doi.org/10.1007/BF01621812

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01621812

Key words

  • Monitoring, pulse oximetry: neonatal
  • Blood: hemoglobin, fetal