Abstract
Mixed venous oxygen saturation\(S\bar vO_2 \) monitoring has been advocated for some critically ill patients. Patients with end-stage hepatic failure have oxygen consumption rates that are lower than normal. Using the Fick equation, oxygen consumption may be calculated if mixed venous and arterial oxygen tensions (and saturations), hemoglobin, and cardiac output are determined simultaneously. This report describes a unique pattern of changes in\(S\bar vO_2 \) and oxygen consumption in 7 patients undergoing liver transplantation. A previous study correlated plasma carbohydrate (glucose) levels with early hepatic graft survival. After induction, the 7 patients reported here had low oxygen consumption and high\(S\bar vO_2 \) values. The oxygen consumption rates decreased to the lowest point during the anhepatic phase and rose above baseline by the end of the case. The\(S\bar vO_2 \) and oxygen consumption data reported here follow the presence of presumed hepatic metabolic activity (increased CO2 and ionized calcium). Further research must be completed to determine whether these measurements indicate early hepatic nonfunction.
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Baele P, McMichan J, Marsh M, et al. Continuous monitoring of fixed venous oxygen saturation in critically ill patients. Anesth Analg 1982;61:513–517
Jamieson WR, Turnbull KW, Larrieu AJ, et al. Importance of mixed venous saturation in cardiac surgery. Can J Surg 1982;25:538–543
Gore JM, Sloan K. Use of continuous monitoring mixed venous oxygen saturation in the coronary care unit. Chest 1984;86:757–761
Wilson RF, Christensen C, Leblanc LP. Oxygen consumption in critically ill surgical patients. Ann Surg 1972;176:801–804
Mallett S, Kang Y, Freeman J, et al. Prognostic significance of reperfusion hyperglycemia during liver transplantation. Anesth Analg 1989;68:182–185
Carmichael FJ, Lindop MJ, Bachir DB, et al. Anesthesia for hepatic transplantation. Anesth Analg 1985;64:108–116
Kromka M, Cortese D. Pulmonary aspects of chronic liver disease and liver transplantation. Proc Mayo Clin 1985;60:407–418
Van Thiel DH, Schode RR, Gavaler JG, et al. Medical aspects of liver transplantation. Hepatology 1984;4:77–83
Marquez J, Martin D, Virji MA, et al: Cardiovascular depression due to ionic hypocalcemia during hepatic transplantation in humans. Anesthesiology 1986;65:457–461
Waterman PM. Anaesthesia for liver transplantation—a model for the anesthetic management of end stage hepatic failure. J Can Anaesth Soc 1983;30:534–538
Kang YG, Martin D, Marquez J, et al. Intraoperative changes in blood coagulation and thromboelastographic monitoring in liver transplantation. Anesth Analg 1985;64:888–896
Borland L, Roule M, Cook RD. Anesthesia for pediatric orthotopic liver transplantation. Anesth Analg 1985;64:117–124
Altman P, Dittmer DS, eds. Respiration and circulation. Bethesda: Committee on Biological Handbooks, Federation of American Societies for Experimental Biology, 1971
Ciofolo MJ, Clerque F, Devilhiers C, et al. Changes in ventilation, oxygen uptake, and carbon dioxide output during recovery from isoflurane anesthesia. Anesthesiology 1989;70:737–741
Ames RP, Boronski AJ, Solinski AM, et al. Prolonged infusion of angiotensin II and norepinephrine and blood pressure, electrolyte balance and cortisol secretion in normal man and in cirrhosis with ascites. J Clin Invest 1985;44:1171–1186
Van Thiel DA: The liver and the endocrine system. In: Arias IM, Popper H, Schachter D, et al, (eds.) The liver: biology and pathobiology. New York: Raven, 1988:1007–1031
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Spiess, B.D., Tuman, K.J., McCarthy, R.J. et al. Oxygen consumption and mixed venous oxygen saturation monitoring during orthotopic liver transplantation. J Clin Monitor Comput 8, 7–11 (1992). https://doi.org/10.1007/BF01618080
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DOI: https://doi.org/10.1007/BF01618080