Skip to main content

Über die Bindung von Blei an eisenhydroxidhaltige Stoffe in Leber, Niere und Milz vergifteter Rinder

Summary

Lead in liver, spleen and kidney of poisoned cattle is bound to substances containing ferric hydroxide. In liver and kidney the smaller amount of lead is sorbed by ferritin, the greater amount by insoluble ferric hydroxide. In the spleen ferritin and insoluble ferric hydroxide contain approximately the same amount of lead. The insoluble ferric hydroxide particles could be concentrated by digestion of insoluble liver proteins with phenol. They were not identical with hemosiderin. The sorption of lead ions and of other metal ions to ferritin and ferric hydroxide was investigated in vitro. Lead sorption is preferred over the sorption of other metal ions. Reaction of metal ions with the protein shell of ferritin occurred only with copper ions. The sorbed metal ions could be split from ferritin by high concentrations of other metal ions and strongly by hydrogen ions. It seems, that lead binding disturbs the storage of iron in tissues in lead poisoning.

This is a preview of subscription content, access via your institution.

Literatur

  1. 1.

    JUBB, K. V. F. und KENNEDY, P. C. Pathology of Domestic Animals, Vol. 2, S. 334 (1963). Academ. Press, New York.

    Google Scholar 

  2. 2.

    MOESCHLIN, S. Klinik und Therapie der Vergiftungen 4. Aufl. S. 46 (1964), Thieme Verl., Stuttgart.

    Google Scholar 

  3. 3.

    ASONSON, A. L. und HAMMOND, P. B. J. Pharmacol. exper. Therap. 146, 241 (1964).

    Google Scholar 

  4. 4.

    LANG, H. und FINGERHUT, M. Arch. exper. Path. Pharmacol. 235, 41 (1958).

    Google Scholar 

  5. 5.

    IWANTSCHEFF, G. das Dithizon in der Mikro- und Spurenanalyse (1962), Verl. Chemie, Weinheim.

    Google Scholar 

  6. 6.

    KALDOR, J. Austral. J. exper. Biol. 32, 795 (1954).

    Google Scholar 

  7. 7.

    SPECKER, H. und TRÜB, H. Z. f. anal. Chem. 186, 123 (1962).

    Google Scholar 

  8. 8.

    PAPADAKIS, J. Diss. Univ. Freiburg (1965).

  9. 9.

    BEHRENS, H. und TAUBERT, M. Z. f. physiol. Chem. 290, 156 (1952).

    Google Scholar 

  10. 10.

    RÜSSEL, H. Dtsch. tierärztl. Wschr. 75, 313 (1968).

    Google Scholar 

  11. 11.

    MAZUR, A., LITT, J. und SHORR, E. J. biol. Chem. 187, 485 (1950).

    Google Scholar 

  12. 12.

    SETTLEMIRE, C. T. und MATRONE, G. J. Nutrit. 92, 153 (1967).

    Google Scholar 

  13. 13.

    BUTT, E. M., NEUMANN, R. E., GILLMOUR, T. C. und DIDO, S. L. Metal Binding in Medicine, (herausgegeben von M. J. SeVEN und L. A. JOHNSON). S. 43 (1960). J. B. Lippincott Comp., Philadelphia.

    Google Scholar 

  14. 14.

    UNDERWOOD, E. J. und MORGAN, E. H. Austral. J. exper. Biol. 41, 247 (1963).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Additional information

Die Deutsche Forschungsgemeinschaft unterstützte diese Arbeit durch Gewährung einer Sachbeihilfe. Fräulein B. Saacke sei für gewissenhafte Mitarbeit gedankt. Ferner danke ich den Herren Veterinärbeamten der Veterinärämter in Schieiden und Euskirchen für die Probenahmen.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rüssel, H.A. Über die Bindung von Blei an eisenhydroxidhaltige Stoffe in Leber, Niere und Milz vergifteter Rinder. Bull. Environ. Contam. Toxicol. 5, 115–124 (1970). https://doi.org/10.1007/BF01617188

Download citation