Abstract
A current problem after single lung transplantation is the evaluation of graft function during various pathologic conditions of the transplanted lung. In 10 single lung recipients, of which six had a parenchymal lung disease, and four pulmonary hypertension, relative perfusion of the transplanted lung\((\dot Q_{tx} )\) was determined with multidetector 133-Xe radiospirometry. The determinations were performed seven times during acute rejection, nine times during infection, and four times during simultaneous rejection and infection. In the patients with a follow-up period over 5 months, the effect of bronchiolitis obliterans syndrome on perfusion was assessed as well. Statistically significant decrease in the\(\dot Q_{tx} \) was observed during acute rejection, whereas the perfusion change during infection was not significant. The\(\dot Q_{tx} \) tended to decrease during long-term follow-up, and the decrease was more prominent in the patients who developed bronchiolitis obliterans syndrome. The assessment of the\(\dot Q_{tx} \) with radiospirometry distinguishes acute rejection from infection and can be used for differential diagnostic aid after single lung transplantation.
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Ikonen, T., Harjula, A.L.J., Savola, J. et al. Effects of acute rejection, infection, and chronic rejection on the perfusion of single lung grafts as assessed by 133-XE radiospirometry. International Journal of Angiology 6, 217–221 (1997). https://doi.org/10.1007/BF01616215
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DOI: https://doi.org/10.1007/BF01616215