Summary
The study investigated the possibility of influencing immunotoxic effects of Cd through ascorbic acid. Guinea pigs with high and low intake of ascorbic acid were perorally exposed to cadmium chloride (1 mg Cd/animal/day).
The daily vitamin C intake was 2 and 100 mg per animal, respectively. Phagocytic activity of polymorphonuclear leucocytes and monocytes as well as the percentage of active and total T lymphocytes in peripheral blood of animals were evaluated.
Five- and 12-week experiments showed a mutual potentiation of negative effects of Cd on the immune system by suboptimal intake of ascorbic acid. Toxic effects of Cd on the immune system can be reduced by a sufficient intake of vitamin C.
Zusammenfassung
Es wurde der Einfluß von Ascorbinsäure auf die immunotoxischen Wirkungen von Cadmium untersucht.
Cadmiumchlorid-exponierte Meerschweinchen (1 mg Cadmium/Tier/Tag) mit hoher (100 mg/Tier) und niedriger (2 mg/Tier) Ascorbinsäurezufuhr wurden auf die phagozytäre Aktivität der polymorphkernigen Leukozyten und Monozyten sowie auf die prozentualen Anteile der aktiven und gesamten T-Lymphozyten des peripheren Blutes untersucht.
Die 5 und 12 Wochen durchgeführten Versuche zeigten, daß Cadmium bei niedriger Ascorbinsäurezufuhr eine negative Wirkung auf das Immunitätsystem hat. Diese toxische Wirkung von Cadmium auf das Immunitätsystem kann durch ausreichende Ascorbinsäurezufuhr verringert werden.
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Kubová, J., Tulinská, J., Štolcová, E. et al. The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium. Z Ernährungswiss 32, 113–120 (1993). https://doi.org/10.1007/BF01614754
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DOI: https://doi.org/10.1007/BF01614754