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Side chain oxidation of ifosfamide in man

Seitenkettenoxidation des Ifosfamids beim Menschen

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Zusammenfassung

Ifosfamid wurde neben seinen stabilen, alkylierenden Metaboliten Carboxy-Ifosfamid und zwei dechloräthylierten Produkten im Urin eines Patienten mit Bronchial-Carcinoma, dem 6 g des Mittels infundiert worden waren, zeitabhängig bestimmt. Zur quantitativen Analyse diente ein dünnschichtspektrometrisches Verfahren, bei dem 4-Pyridinaldehyd-2-benzothiazolylhydrazon als Chromogen eingesetzt wird. Im Fall des untersuchten Patienten wurde Ifosfamid vorwiegend in zwei dechloräthylierte Produkte umgewandelt (48% der gegebenen Dosis) und nur in geringem Umfang in Carboxy-Ifosfamid (2,2%).

Summary

Ifosfamide as well as its stable alkylating metabolites namely carboxy-Ifosfamide and two dechloroethylated compounds were determined in the urine of a patient with progredient lung carcinoma who had been treated with 6 g of the drug. Quantitative measurements were carried out using a colorimetric procedure which consists of TL-spectrophotometric determinations on sheets which had previously been sprayed with 4-pyridinaldehyde-2-benzothiazolylhydrazone. In the case investigated the Ifosfamide was found to have been converted largely into two dechloroethylated compounds (48%) and only a small portion of carboxy-Ifosfamide (2.2%).

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Authors and Affiliations

  1. Institut für Staublungenforschung und Arbeitsmedizin der Westfälischen Wilhelms-Universität Münster, Germany

    K. Norpoth, H. Raidt, U. Witting, G. Müller & R. Norpoth

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  1. K. Norpoth
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  2. H. Raidt
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  3. U. Witting
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  4. G. Müller
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  5. R. Norpoth
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Norpoth, K., Raidt, H., Witting, U. et al. Side chain oxidation of ifosfamide in man. Klin Wochenschr 53, 1075–1076 (1975). https://doi.org/10.1007/BF01614384

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  • DOI: https://doi.org/10.1007/BF01614384

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