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Impairment of granulocyte function in juvenile diabetes

Störung der Granulocytenfunktion bei diabetischen Kindern

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Zusammenfassung

Bei 10 Kindern mit Diabetes wurde die Funktion der Granulocyten getestet. Zum Zeitpunkt der Untersuchung waren die Patienten schlecht eingestellt. Fünf Kinder wurden nach Korrektur der Insulindosis und der Diät eine Woche später erneut getestet. Im Gegensatz zu Berichten aus der Literatur fanden wir keine verringerte Ingestion von Partikeln. Dagegen war die intracelluläre Abtötung von Staphylococcus aureus gestört. Die chemotaktische Aktivität war ebenfalls verringert, während der NBT-Index und die intracelluläre Abtötung von Candida albicans normal waren. Optimale Einstellung des Diabetes führte zu einer Verbesserung der Abtötungsfähigkeit gegenüber Bakterien.

Summary

Granulocyte function of 10 diabetic children has been investigated. At the time of testing the diabetes was in poor control. Five children were retested one week later after adjustment of diet and insulin dose. In contrast to some reports we did not find a phagocytic defect in the ingestion of particles, but the capacity of intracellular killing of Staphylococcus aureus was impaired. Chemotaxis was also reduced whereas the NBT-index and intracellular killing of Candida albicans were normal. Better control of the diabetes led to an improvement of bactericidal killing capacity.

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Authors and Affiliations

  1. Department of Pediatrics, University of Ulm, Germany

    D. Niethammer, E. Heinze, W. Teller & E. Kleihauer

  2. Department of Pathology I, University of Ulm a.d. Donau, Germany

    A. Wildfeuer & O. Haferkamp

Authors
  1. D. Niethammer
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  2. E. Heinze
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  3. W. Teller
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  4. E. Kleihauer
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  5. A. Wildfeuer
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  6. O. Haferkamp
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Supported by the Deutsche Forschungsgemeinschaft.

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Niethammer, D., Heinze, E., Teller, W. et al. Impairment of granulocyte function in juvenile diabetes. Klin Wochenschr 53, 1057–1060 (1975). https://doi.org/10.1007/BF01614381

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  • DOI: https://doi.org/10.1007/BF01614381

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