Zusammenfassung
Die biliäre Reexkretion von Bromsulfthalein (BSP) (1,2 µmol/Ratte) wird nach retrograder Injektion in das Gallengangssystem der Ratte durch intravenöse Gabe von Decholin entweder als Infusion (3,1 µmol/min/kg Körpergewicht) oder als Bolusinjektion (24,8 µmol/Ratte) signifikant eingeschränkt. Decholin hemmt auch dann die biliäre Reexkretion von BSP, wenn 24,8 µmol/Ratte zusammen mit BSP retrograd injiziert werden. Die biliäre Rückresorption erscheint dagegen gesteigert: ca 80–85% von 1,2 µmol BSP werden nach retrograder Injektion in das Gallengangssystem der Ratte unter dem Einfluß von Decholin rückresorbiert im Vergleich zu ca 65% der Kontrollgruppe. Unter Berücksichtigung histologischer Befunde wird vermutet, daß BSP nach retrograder Injektion im duktulären Bereich des Gallengangssystems rückresorbiert wird, während die biliäre Reexkretion an der Canaliculusmembran des Hepatozyten stattfindet.
Summary
Biliary re-excretion of sulfobromophthalein sodium (BSP) (1.2 µmol/rat) after retrograde intrabiliary injection is markedly inhibited by dehydrocholate sodium (Decholin) given intravenously as a constant infusion (3.1 µmol/min/kg body weight) or as a bolus injection (24.8 µmol/rat) to rats. Most interestingly Decholin demonstrates the same inhibitory effects on the biliary re-excretion of BSP when it is administered by retrograde intrabiliary injection (24.8 µmol/rat) together with the dye. In contrast to the inhibition of biliary re-excretion of BSP its biliary reabsorption from the biliary tract seems to be rather increased: about 80–85% of 1.2 µmol BSP are reabsorbed in all sets of experiments with Decholin in comparison to about 65% to the control group. Combined with histological data it is suggested that reabsorption of BSP after retrograde intrabiliary injection occurs at the ductular site whereas re-excretion takes place at the cannalicular membrane of the hepatocyte.
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References
Barber-Riley, G.: Measurement of capacity of biliary tree in rats. Amer. J. Physiol.205, 1122; 1963a
Barber-Riley, G.: Rat biliary tree during short periods of obstruction of common duct. Amer. J. Physiol.205, 1127; 1963b
Bloomer, J.R., Boyer, J.L., Klatskin, G.: Inhibition of bilirubin excretion in man during dehydrocholate choleresis. Gastroenterology65, 929; 1973
Cantarow, A., Wirts, C.W. Jr.: The effect of dogs bile, certain bile acids and india ink on bilirubinemia and the excretion of bromsulfalein. Am. J. Dig. Dis.10, 261; 1943
Clark, A.G., Hirom, P.C., Millburn, P., Smith, R.L.: Absorption of some organic compounds from the biliary system of the rat. J. Pharm. Pharmacol.23, 150; 1971
Czok, G., Dammann, H.G.: Evidence of absorption of bromsulphothalein from the biliary system of the rat. J. Parm. Parmacol.24, 820; 1972
Dammann, H.G., Czok, G.: Differences of reabsorption of unconjugated BSP and BSP—glutathione from the rat biliary tree after retrograde intrability injection. Res. exp. Med., 165, 181, 1975
Dammann, H.G., Otto, H.F.: unpublished data
Neuberger, H.O., Zelder, O., and Bode, C.: Secretin and bile salt induced choleresis in patients with and without diseases of the liver and biliary tract (abstr.). Gastroenterology 62, 1972
Whelan, G., Hoch, J., Combes, B.: A direct assessment of the importance of conjugation for biliary transport of sulfobromophthalein sodium. J. Lab. clin. Med. 75, 542; 1970
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Dammann, H.G., Süßenbach, J. & Czok, G. Influence of dehydrocholate sodium on the biliary reabsorption of sulfobromophthalein sodium from the rat biliary tree after retrograde intrabiliary injection. Klin Wochenschr 54, 789–791 (1976). https://doi.org/10.1007/BF01614296
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DOI: https://doi.org/10.1007/BF01614296