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Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma

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  • Clinical Oncology
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Summary

HLA-A and B antigens were determined in a study of 162 patients (93 epidermoid type, 20 adenocarcinoma, 26 small-cell carcinoma and 23 undifferentiated types) with lung cancer. Differences between antigen frequencies in cancer and control populations were studied by χ 2Y analysis or Fisher's exact test. Survival data were analyzed using Cox's model for censored data. Cancer patients had a decreased frequency of the antigen HLA-B40 (χ 2Y =14.15,P=0.00018,P c=0.003, relative risk=0.21). Patients with HLA-A10, A 11 and B27 had a shortened mean survival time. Patients with HLA-B12 had a prolonged survival time.

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Authors and Affiliations

  1. Institute of Haematology and Blood Transfusion, U nemocnice 1, CS-128 00, Prague 1, Czechoslovakia

    J. Pražák

  2. Clinic of Tuberculosis and Respiration Disease, Faculty of General Medicine, Charles University, Prague, Czechoslovakia

    O. Měřička

  3. Institute of Biophysics and Nuclear Medicine, Faculty of General Medicine, Charles University, Prague, Czechoslovakia

    J. Chytrý

Authors
  1. J. Pražák
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  2. O. Měřička
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  3. J. Chytrý
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Pražák, J., Měřička, O. & Chytrý, J. Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma. J Cancer Res Clin Oncol 116, 525–527 (1990). https://doi.org/10.1007/BF01613006

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  • DOI: https://doi.org/10.1007/BF01613006

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