Summary
The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.
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Abbreviations
- R,R/S,S :
-
racemate
- R,S :
-
meso
References
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Dedicated to Professor Dr. D. Schmähl on the occasion of his 65th birthday
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vom Orde, H.D., Reile, H., Müller, R. et al. Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. J Cancer Res Clin Oncol 116, 434–438 (1990). https://doi.org/10.1007/BF01612989
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DOI: https://doi.org/10.1007/BF01612989