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DNA repair at the level of the gene: molecular and clinical considerations

  • Guest Editorial
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Summary

DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably. One recent advance is our capability to analyze the fine structure of DNA damage and repair by measuring the formation of lesions and their repair in specific, important genes in rodent and human cells. Such studies are leading to increased understanding of the molecular and clinical aspects of DNA repair.

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Abbreviations

CHO:

Chinese hamster ovary

DHFR:

dihydrofolate reductase

XP:

xeroderma pigmentosum

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Authors and Affiliations

  1. Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, Bldg. 37, Rm 5A-19, 20892, Bethesda, MD, USA

    Vilhelm A. Bohr

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  1. Vilhelm A. Bohr
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Additional information

The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author.

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Bohr, V.A. DNA repair at the level of the gene: molecular and clinical considerations. J Cancer Res Clin Oncol 116, 384–391 (1990). https://doi.org/10.1007/BF01612922

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  • DOI: https://doi.org/10.1007/BF01612922

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