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Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats

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References

  • Agarwal DK, Seth PK, Gupta PK (1978) Effect of endo sulfan on drug metabolizing enzymes and lipid peroxidation on rat. J Environ Sci Health 13:49–62.

    Google Scholar 

  • Bickers DR, Kappas A, Alvares AP (1974) Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P-450 by polychlorinated biphenyls and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT). J pharmacol Exp Ther 188:300–309.

    Google Scholar 

  • Boyd MR (1980) Biochemical mechanism in chemical-induced lung injury:roles of metabolic activation. CRC Crit Rev Toxicol 7:103–76.

    Google Scholar 

  • Boyd MR, Stiko A, Statham CN, Jones RB (1982) Protective role of endogenous glutathione and other sulfhydril compounds against lung damage by alkylating agents. Investigation with 4-ipomeanol in the rat. Biochem Pharmacol 31:1579–1583.

    Google Scholar 

  • Bunyan PJ, Page JM (1973) Pesticide induced changes in hepatic microsomal enzyme systems. Some effects of 1,1-di (p-chlorophenyl)-2, 2-dichloroethylene (DDE) and 1,1-di (p-chlorophenyl)-2-chloro ethylene (DDMU) in the rat and Japanese quail. Chem Biol Interact 6:249–257.

    Google Scholar 

  • Bunyan PJ, Taylor A, Townsend MG (1970) The effects of 1,1-di(p-chlorophenyl)-2,2,2-trichloroethane (DDT) and 1,1-di(p-chlorophenyl)-2,2-dichloroethylene (DDE) on hepatic microsomal oxidase in the rat and Japanese quail. Biochem J 118:51–52.

    Google Scholar 

  • Casida JE (1978) Advances in pesticide science: Part 1-world food production. Environmental pesticides, ed. H. Geissbuhler (Pergmen Press, London) pp 45–53.

    Google Scholar 

  • Christensen F, Wissing F (1972) Inhibition of microsomal drug-metabolizing enzymes from rat liver by various 4-hydroxycoumarin derivatives. Biochem Pharmacol 21: 975–984.

    Google Scholar 

  • Copeland MF, Crammer MF (1974) Effect of o,p-DDT on the adrenal gland and hepatic microsomal system in the beagle dog. Toxicol Appl Pharmacol 27:1–10.

    Google Scholar 

  • Dorough HW, Huhtanen K, Marshal TC, Brayant HE (1978) Fate of endosulfan in rats and toxicological considerations of apolar metabolites. Pestic Biochem Physiol 8:241–252.

    Google Scholar 

  • Down WH, Chasseaud LF (1978) The effect of DDT on hepatic microsomal drug metabolizing enzymes in the baboon: Comparision with the rat. Bull Environ Contam Toxicol 20:592–601.

    Google Scholar 

  • Down WH, Chasseaud LF (1981) Hepatic microsomal drug metabolizing enzyme activity in non-human primates. The effect of repeated oral administration of DDT to baboons and Rhesus monkeys. Comp Biochem Physiol 69C:165–168.

    Google Scholar 

  • Dunbar JR, Delucia AJ, Brayant LR (1981) Effects of introfuration on the glutathione redox status and related enzymes in the isolated perfused rabbit lung. Res Commun Chem Pathol Pharmacol 34:485–492.

    Google Scholar 

  • Gillette JR, Mitchell JR, Brodie BB (1974) Biochemical mechanism of drug toxicity. Ann Rev Pharmacol 14:271–288.

    Google Scholar 

  • Gram TE (1980) The metabolism of xenobiotics by mammalian lung. In Extrahepatic metabolism of drugs and other foreign compounds. ed. TE Gram, pp 159–209. New York/London: sp Medical and scientific books, 601 pp.

    Google Scholar 

  • Gupta PK, Gupta RC (1979) Pharmacology, Toxicology and degradation of endosulfan. A review. Toxicology 13:115–130.

    Google Scholar 

  • Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione-s-transferase. First enzymic step in mercapturic acid formation. J Biol Chem 249:7130–7139.

    Google Scholar 

  • Imai Y, Ito A, Sato R (1966) Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem (Tokyo) 60:417–428.

    Google Scholar 

  • Kato R, Gillette JR (1965) Effect of starvation on NADPH dependent enzymes in liver microsomes of male and female rats. J Pharmacol Exp Ther 150:279–284.

    Google Scholar 

  • Keizomaita CHK, Steight SD, Hook JB (1983) Lipid peroxidation: A possible mechanism of cephaloridine-induced nephrotoxicity. Toxicol Appl Pharmacol 67:78–88.

    Google Scholar 

  • Lowry OH, Rosebrough NJ, Narr AL, Randall AJ (1951) Protein measurement with Folin Phenol reagent. J Biol Chem 193: 265–275.

    Google Scholar 

  • Omura T, Sato R (1964) A carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370–2378.

    Google Scholar 

  • Peterson JE, Robinson WH (1964) Metabolic products of p,p′-DDT in the rat. Toxicol Appl Pharmacol 6:321–327.

    Google Scholar 

  • Remmer H (1974) Pulmonary drug metabolizing enzymes. In Lung metabolism, ed. AF Junod, R deHaller, pp 133–158.

  • Ritter CL, Malejka-Giganti D (1982) Mixed function oxidase in the mammary gland and liver microsomes of lactating rats. Biochem Pharmacol 31:239–247.

    Google Scholar 

  • Sell JL, Davison KL, Kockanda B (1972) Decreased aniline hydroxylase activity in Japanese quail due to dietary DDT. J Agri Food Chem 20:553–557.

    Google Scholar 

  • Smith BR, Bend JR (1981) Biochemical mechanisms in pulmonary toxicity of furan derivatives: In Reviews in Biochemical Toxicology, ed. E Hodgson, JR Bend, RM Philpot, 3 : 77–122, New York, Elsevier/North-Holland 300 pp.

    Google Scholar 

  • Steel JW, Hernadez O, Cox RH, Smith BR, Bend JR (1981) The metabolism and excretion of styrene oxide-glutathione conjugates in the rat and byisolated perfused liver, lung and kidney preparations. J pharmacol Exp Ther 219: 35–41.

    Google Scholar 

  • Tyagi SR, Singh Y, Srivastava PK, Misra UK (1983) Induction of hepatic mixed function oxidase system by endosulfan in rats. Bull Environ Contamin Toxicol (in press).

  • Witschi H, Cote MG (1977) Primary pulmonary responses to toxic agents. CRC Crit Rev Toxicol 5:23–66.

    Google Scholar 

  • Zannoni VG, Flynn EJ, Lynch M (1972) Ascorbic acid and drug metabolism. Biochem Pharmacol 21: 1377–1392.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, VP Chest Institute, Delhi University, 110007, Delhi, India

    Satya Narayan, A. Bajpai, S. R. Tyagi & U. K. Misra

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  1. Satya Narayan
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  2. A. Bajpai
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  3. S. R. Tyagi
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  4. U. K. Misra
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Narayan, S., Bajpai, A., Tyagi, S.R. et al. Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats. Bull. Environ. Contam. Toxicol. 34, 55–62 (1985). https://doi.org/10.1007/BF01609702

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  • DOI: https://doi.org/10.1007/BF01609702

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