Skip to main content
Log in

Di(2-ethylhexyl)adipate (DEHA): Effect on plasma lipids and hepatic cholesterolgenesis in the rat

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bell FP (1976) Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-2-ethylhexyl phthalate. Lipids 11:769–773

    Google Scholar 

  • Bell FP, Nazir DJ (1976) Effect of dietary di-2-ethylhexyl phthalate on lipid biosynthesis in selected tissues from the rat, in vitro. Lipids 11:216–221

    Google Scholar 

  • Bell FP, Patt CS, Gillies PJ (1978) Effect of phthalate esters on serum cholesterol and lipid biosynthesis in liver, testes, and epididymal fat in the rat and rabbit. Lipids 13:673–678

    Google Scholar 

  • Bell FP (1982) Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals. Environ Hlth Perspect 45:41–50

    Google Scholar 

  • Bell FP (1983a) Carnitine esters: novel inhibitors of plasma lecithin:cholesterol acyltransferase in experimental animals but not in man (homo sapiens). Int J Biochem 15:133–136

    Google Scholar 

  • Bell FP (1983b) Effect of the plasticizer di(2-ethylhexyl)adipate (dioctyladipate, DOA) on lipid metabolism in the rat. I. Inhibition of cholesterolgenesis and modification of phospholipid synthesis. Lipids 18:211–215

    Google Scholar 

  • Daly MM (1971) Biosynthesis of squalene and sterols by rat aorta. J Lipid Res 12:367–375

    Google Scholar 

  • Dietschy JM, Brown MS (1974) Effect of alterations of the specific activity of the intracellular acetylCoA pool on apparent rates of hepatic cholesterogenesis. J Lipid Res 15:508–516

    Google Scholar 

  • Folch J, Lees M, Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509

    Google Scholar 

  • Gangolli SD (1982) Testicular effects of phthalate esters. Environ Hlth Perspect 45:77–84

    Google Scholar 

  • Glomset JA (1979) Lecithin:cholesterol acyltransferase. An exercise in comparative biology. Prog Biochem Pharmac 15:41–66

    Google Scholar 

  • Huff J (1982) Di(2-ethylhexyl)adipate: Condensation of the carcinogenesis bioassay technical report. Environ Hlth Perspect 45:205–207

    Google Scholar 

  • Lacko AG, Rutenberg HL, Soloff LA (1973) Measurement of the initial rate of serum cholesterol esterification. Biochetn Med 7:178–183

    Google Scholar 

  • Lagente M, de La Farge F, Valdiguie P (1979) The influence of phthalate esters on human plasma lecithin:cholesterol acyltransferase. Lipids 14:533–534

    Google Scholar 

  • Lagente M, de La Farge F, Valdiguie P (1978) Effects des esters de l'acide phtalique sur la lecithine-cholesterol-acyltransferase CR Acad Sc Paris 287 (Series D):361–364

    Google Scholar 

  • Reddy JK, Moody DE, Azarnoff DL, Rao MS (1976) Di-(2-ethylhexyl) phthalate: an industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rats and mice. Life Sci 18:941–946

    Google Scholar 

  • Royer ME, Ko H (1972) Automatic extraction and analysis of serum triglycerides. Biochem Med 6:144–159

    Google Scholar 

  • Rusoff II, Baldwin RR, Domingues FJ, Monder C, Ohan WJ, Thiessen R Jr (1960) Intermediary metabolism of adipic acid. Toxicol Appl Pharmacol 2:316–330

    Google Scholar 

  • Seth PK (1982) Hepatic effects of phthalate esters. Environ Hlth Perspect 45:27–34

    Google Scholar 

  • Sperry WM, Webb M (1950) A revision of the Schoenheimer-Sperry method for cholesterol determination. J Biol Chem 187:97–106

    Google Scholar 

  • Takahashi T, Tanaka A, Yamaha T (1981) Elimination, distribution and metabolism of di(2-ethylhexyl)adipate (DEHA) in rats. Toxicology 22:223–233

    Google Scholar 

  • Warren JR, Lalwani ND, Reddy JK (1982) Phthalate esters as peroxisome proliferator carcinogens. Environ Hlth Perspect 45:35–40

    Google Scholar 

  • Yanagita T, Kobayashi K, Enomoto N (1978) Accumulation of hepatic phospholipids in rats fed di-2-ethylhexyl phthalate. Biochem Pharmacol 27:2283–2288

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bell, F.P. Di(2-ethylhexyl)adipate (DEHA): Effect on plasma lipids and hepatic cholesterolgenesis in the rat. Bull. Environ. Contam. Toxicol. 32, 20–26 (1984). https://doi.org/10.1007/BF01607460

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01607460

Keywords

Navigation