Summary
We investigated the clinicopathological findings in five cases of multicystic mesothelial proliferation (MMP). All masses consisted of multiloculated cysts attached to pelvic organs and sometimes growing into the upper abdominal cavity. The cystic spaces were lined by flattened or cuboidal cells. The stroma showed fibrosis, oedema and chronic inflammation. Immunohistochemistry revealed strong positive staining for cytokeratin and epithelial membrane antigen, and focal positivity for vimentin and carcinoembryonic antigen. The endothelial markers were negative. Electron microscopy showed abundant surface microvilli and well-developed basal lamina. DNA analysis identified euploid cell populations in all cases. All but one case had a previous history of abdominal surgery. Despite the worrying appearance the clinical outcome was favourable in all cases; there was one recurrence. Clinical and pathological data support the hypothesis that MMP represent a reactive mesothelial proliferation and not a neoplastic process.
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References
Alvarez-Fernandez E, Rabano A, Barros-Malvar JL, Sanabia-Valdez J (1989) Multicystic peritoneal mesothelioma: a case report. Histopathology 14:199–208
Auer GU, Askensten U, Erhardt K, Fallenius A, Zettergerg A (1980) Comparison between slide and flow cytophotometric DNA measurements in breast tumors. Anal Quant Cytol Histol 2:138–146
Ball NJ, Urbanski SJ, Green FHY, Kieser T (1990) Pleural multicystic mesothelial proliferation. The so-called multicystic mesothelioma. Am J Surg Pathol 14:375–378
Canty M, Williams J, Volpe RJ, Yunan E (1990) Benign cystic mesothelioma in a male. Am J Gastroenterol 85:311–315
Decosse JJ, Aiello N (1966) Feulgen hydrolysis: effect of acid and temperature. J Histochem Cytochem 14:601–604
De Rosa G, Boscaino A, Terracciano L, Giordano G (1992) Giant adenomatoid tumors in the uterus. Int J Gynecol Pathol 11:156–160
Gonzales-Crussi F, Sobelo-Avila C, Mello DE de (1986) Primary peritoneal, omental and mesenteric tumors in childhood. Semin Diagn Pathol 3:122–137
Gusman D, Tickman D, Wheeler JE (1986) Post-operative peritoneal cysts. Obstet Gynecol 68:53S-55S
Hamdi H, Louthai M, Schevket D (1927) Uber drei seltene Bauchfellgeschwulste. Beitr Pathol Anat 78:249–259
Hidvégi J, Schneider F, Rohonyi B, Flautner L, Szlávik L (1991) Peritoneal benign cystic mesothelioma. Pathol Res Pract 187:103–106
Hsu S, Raine L, Fanger H (1981) The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Iversen OH, Hovig T, Brandtzaeg P (1988) Peritoneal, benign, cystic mesothelioma with free-floating cysts, re-examined by new methods. APMIS 96:123–127
Jacobson ES (1974) Benign papillary peritoneal cystosis simulating serous cystadenocarcinoma of the ovary. Am J Obstet Gynecol 118:575–576
Jones EG, Donovan AJ (1965) Adenomatoid tumor of the ovary versus mesothelial reaction. Am J Obstet Gynecol 92:694–698
Katsube Y, Mukai K, Silverberg G (1982) Cystic mesothelioma of the peritoneum. Cancer 50:1615–1622
Kjellevold K, Nesland JM, Holm R, Johannessen JV (1986) Multicystic peritoneal mesothelioma. Pathol Res Pract 181:767–771
Lees RF (1978) Inflammatory cysts of the pelvic peritoneum. Aust Radiol 22:319–324
McCaughey WTE, Kannerstein M, Churg J (1985) Tumors and pseudotumors of the serous membranes. Atlas of tumor pathology, series 2, fascicle 20. Armed Forces Institute of Pathology Washington, DC, pp 76–78
McFadden DE, Clement PB (1986) Peritoneal inclusion cysts with mural mesothelial proliferation. Am J Surg Pathol 10:844–854
Mennemeyer R, Smith M (1979) Multicystic peritoneal mesothelioma: a case report with electronmicroscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer 44:692–698
Miles JN, Hart WR, McMahan JT (1986) Cystic mesothelioma of the peritoneum: report of a case with multiple recurrences and review of the literature. Cleve Clin Q 53:109–114
Monafo W, Golfarb W (1963) Post-operative peritoneal cyst. Surgery 53:470–473
Moore JH, Crum CP, Chandler JG, Feldman PS (1980) Benign cystic mesothelioma. Cancer 45:2395–2399
Plaut A (1928) Multiple peritoneal cysts and their histogenesis. Arch Pathol 5:754–756
Ross MJ, Welch WR, Scully RE (1989) Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer 64:1336–1346
Sienkowski JK, Russell AJ, Dilly SA, Djazaer B (1986) Peritoneal cystic mesothelioma: an electron microscopic and immunohistochemical study of two male patients. J Clin Pathol 39:440–445
Sternberg SS, Miles SE (1991) Surgical pathology of the female reproductive system and peritoneum. Raven Press, New York, pp 269–271
Weiss SW, Tavassoli FA (1988) Multicystic mesothelioma. Am J Surg Pathol 12:737–747
Zeppa P, Poel HG van der, Boon ME, Kurniawan AN, Kok LP (1991) A model for quantitative follow-up studies of cervical lesions. Diagn Cytopathol 7:1–10
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De Rosa, G., Donofrio, V., Boscaino, A. et al. Multicystic mesothelial proliferation. Vichows Archiv A Pathol Anat 421, 379–385 (1992). https://doi.org/10.1007/BF01606909
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DOI: https://doi.org/10.1007/BF01606909