Skip to main content

Quinine inducedEscherichia coll DNA base-pair substitution mutation

This is a preview of subscription content, access via your institution.


  1. Aung-than-Batu, Htun Nyum R, Nyun Hlaing, Franco Tin, Tin U, Than Myint, Khin Kyi Kyi (1975)Chloroquine-resistant malaria in Burma.J Trop Med Hyg 78:186–189

    Google Scholar 

  2. Brusick DJ, Simmons VF, Rosenkranz HS, Ray VA, Stafford RS (1980)An evaulation of the Escherichia coli WP2 and WP2 uvrA reverse mutation assay.Mutat Res 76:169–190

    Google Scholar 

  3. Davis BD, Mingioli ES (1950)Mutants of E. coli requiring methionine or vitamin B 12.J Bacteriol 60:17–28

    Google Scholar 

  4. Estensen RD, Krey AK, Hahn FE (1969)Studies on a deoxyribomuleic acid-quinine complex.Molec Pharmacol 5:532–541

    Google Scholar 

  5. Green MHL, Muriel WJ (1976)Mutagen testing using trp + reversion inE. coli.Mutat Res 38:3–32

    Google Scholar 

  6. Green MHL, Muriel WJ, Bridges BA (1976)Use of a simplified fluctuation test to detect low levels of mutagens.Mutat Res 38:33–42

    Google Scholar 

  7. Green MHL (1984) Mutagen testing using trp reversion in Escherichia coli In: Handbook of mutagenicity test procedures. 2nd ed Elsevier Science Publishers

  8. Hahn FE, Fean CL (1969) Spectrophotometric studies of the interaction of an antimalarial quinoline methanol with deoxyribonucleic acid. Antimicrob J Chemother 63–66

  9. Hall AP (1976)The treatment of malaria.Brit Med J V:323

    Google Scholar 

  10. Levin EE, Yanrasaki E, Ames BN (1982)A new Salmonella tester strain, TA97 for the detection of frameshift mutagens. A run of cytosines as a mutational hot-spot.Mutat Res 94:315–330

    Google Scholar 

  11. Maron DN, Ames BN (1983)Revised methods for the Salmonella mutagenicity tests.Mutat Res 113;173–215

    Google Scholar 

  12. Obaseiki-Ebor EE (1984)Resistance to nitrofurantoin and UV-irradiation in recA; uvrA; anduvrA lexA E. coli mutants conferred by an R-plasmid from an E. coli clinical isolate.Mutat Res 139:5–8

    Google Scholar 

  13. O'Brien RL, Olenick JG, Hahn FE (1966)Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.Biochemistry 55:1511–1516

    Google Scholar 

  14. Schupbach ME (1979)Mutagenicity evaluation of the two antimalarial agents chloroquine and mefloquine using a bacterial fluctuation test.Mutat Res 68:41–49

    Google Scholar 

  15. Strub RE (1975)The search for new antimalarial drugs.J Trop Med Hyg 78:171–185

    Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Obaseiki-Ebor, E.E., Obasi, E.E. Quinine inducedEscherichia coll DNA base-pair substitution mutation. Bull. Environ. Contam. Toxicol. 38, 422–425 (1987).

Download citation


  • Waste Water
  • Water Management
  • Water Pollution
  • Quinine
  • Substitution Mutation