Summary
The glomerular peripolar cell may be a secretory component of the juxtaglomerular apparatus. To investigate this hypothesis we studied kidneys with the renin-angiotensin system activated by two different stimuli in order to compare the responses of peripolar cells and renin-secreting cells. We examined 10 human kidneys, removed for renal artery stenosis and 11 autopsy cases of Addison's disease with appropriate controls. We counted granulated peripolar cells in serial paraffin-embedded sections and renin-containing cells were quantified using an immunoperoxidase technique with an antiserum to human renin. There was a five-fold increase in the number of renin-containing cells in both renal artery stenosis and in untreated, but not in treated, Addison's disease. Peripolar cells were increased in number in three cases of renal artery stenosis, but were unaltered in both treated and untreated Addison's disease. Therefore, neither a reduction in renal perfusion pressure (renal artery stenosis), nor sodium depletion (Addison's disease) consistently affect peripolar cells in humans. These findings do not support the hypothesis that the peripolar cell is part of the juxtaglomerular apparatus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alexander F (1968) The juxtaglomerular apparatus in Addison's disease. J Pathol 96:27–32
Anderson JR (1985) Primary adrenocortical hypofunction. In: Anderson JR (ed) Mur's textbook of pathology, 12th edn. Arnold, London, pp 26.35–26.38
Berlyne GM, Tavill AD, Baker SB de (1964) Renal artery stenosis and the nephrotic syndrome. Q J Med 33:325–335
Brown JJ, Davies DL, Lever AF, Robertson JIS (1964) Variations in plasma renin concentration in several physiological and pathological states. Can Med Assoc J 90:201–206
Camilleri JP, Phat VN, Bariety J, Corvol P, Menard J (1980) Use of a specific antiserum for renin detection in the human kidney. J Histochem Cytochem 28:1343–1346
Cantin M, Gutkowska J, Lacasse J, Ballak M, Ledoux S, Inagami T, Beuzeron J, Genest J (1984) Ultrastructural immunocytochemical localisation of renin and angiotensin II in the juxtaglomerular cells of the ischaemic kidney in experimental renal hypertension. Am J Pathol 115:212–224
Christensen JA, Bader H, Bohle A, Meyer DS (1976) The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and Conn's syndrome. Virchows Arch [A] 370:103–112
Dhiab al Naimy AAH, Bearn JG (1981) The role of the adrenals in the development of the glomerular granular cells in foetal and neonatal rats. J Anat 132:466–467
Farragiana T, Gresik E, Tanaka T, Inagami T, Lupo A (1982) Immunohistochemical localisation of renin in the human kidney. J Histochem Cytochem 30:1343–1346
Gall JAM, Alcorn D, Butkus A, Coghlan JP, Ryan GB (1986) Distribution of glomerular peripolar cells in different mammalian species. Cell Tissue Res 244:203–208
Gardiner DS, Lindop GBM (1985) The granular peripolar cell of the human glomerulus: a new component of the juxtaglomerular apparatus? Histopathology 9:675–685
Gardiner DS, Lindop GBM (1992) The glomerular peripolar cell — an immunohistochemical study. APMIS (in press)
Gardiner DS, Downie I, Gibson IW, More IAR, Lindop GBM (1991) The glomerular peripolar cells: a review. Histol Histopathol 6:567–573
Gibson IW, More IAR, Lindop GBM (1989) A scanning electron microscopic of the peripolar cell of the rat renal glomerulus. Cell Tissue Res 257:201–206
Graham PC, Stewart HVA, Downie I, Lindop GBM (1990) The distribution of renin-containing cells in human kidneys with renal artery stenosis — an immunocytochemical study. Histopathology 16:347–358
Hanner RH, Ryan GB (1980) Ultrastructure of the renal juxtaglomerular complex and peripolar cells in the axolotl (Ambystoma mexicanum) and toad (Bufo marinus). J Anat 130:445–455
Hill PA, Coghlan JP, Scoggins BA, Ryan GB (1983) Ultrastructural changes in the sheep renal juxtaglomerular apparatus in response to sodium depletion or loading. Pathology 15:463–473
Kelly G, Downie I, Gardiner DS, More IAR, Lindop GBM (1990) The peripolar cell: a distinctive cell type in the mammalian glomerulus. Morphological evidence from a study of sheep. J Anat 168:217–227
Kincaid-Smith P, McMichael J, Murphy EA (1958) The clinical course and pathology of hypertension with papilloedema (malignant hypertension). Q J Med 27:117–153
Lendrum AC, Fraser DS, Slidders W, Henderson R (1962) Studies on the character and staining of fibrin. J Clin Pathol 15:401–403
Lindop GBM, Millan DWM, Murray D, Gibson AAM (1987) Immunocytochemistry of renin in renal tumours. Clin Exp Hypertens [A] 9:1305–1323
Montolin J, Boley A, Torras A, Darnell A, Revert L (1979) Renin-induced massive proteinuria in man. Clin Nephrol 11:267–271
Morild I, Christensen JA, Mikeler E, Bohle A (1988) Peripolar cells in the avian kidney. Virchows Arch [A] 412:471–477
Nakajima M, Mathews DC, Hewitson T, Kincaid-Smith P (1989) Modified immunogold labelling applied to the study of protein droplets in glomerular disease. Virchows Arch [A] 415:489–499
Nochy D, Barres D, Camilleri JP, Bariety J, Corvol P, Menard J (1983) Abnormalities of renin-containing cells in human glomerular and vascular renal diseases. Kidney Int 23:375–379
Parving HH, Mogensen CE, Jensen HA, Evrin PE (1974) Increased urinary albumin-excretion rate in benign essential hypertension. Lancet 1:1190–1192
Ryan GB, Coghlan JP, Scoggins BA (1979) The granulated peripolar epithelial cell: a potential secretory component of the renal juxtaglomerular complex. Nature 277:655–656
Scicli AG, Carretero OA (1986) Renal kallikrein-kinin system. Kidney Int 29:120–130
Szokol M, Soltesz M, Varga S (1979) Ultrastructural changes of the rat renal glomeruli in the early phase of renovascular hypertension. Acta Morphol Acad Sci Hung 27:117–132
Taugner R, Hackenthal E, Nobiling R, Harlacher M, Reb G (1981) The distribution of renin in the different segments of the renal arterial tree. Immunocytochemical investigation in the mouse kidney. Histochemistry 73:75–88
Tobian L, Thompson J, Twedt R, Janeck J (1958) The granulation of juxtaglomerular cells in renal hypertension, desoxycorticosterone and post-desoxycorticosterone hypertension, adrenal regeneration hypertension and adrenal insufficiency. J Clin Invest 37:660–671
Trahair JF, Ryan GB (1988) Immunohistochemical identification of plasma proteins in cytoplasmic granules of peripolar cells of the sheep. J Anat 160:109–115
Trahair JF, Gall JA, Alcorn D, Coghlan JP, Fernley R, Penschau J, Grattage LP, Johnston CI, Ryan GB (1989) Immunohistochemical study of peripolar cells of the sheep. J Anat 162:125–132
Turgeon C, Sommers SC (1961) Juxtaglomerular cell counts and human hypertension. Am J Pathol 38:227–241
Turner DR (1985) Granular peripolar cells, renin and the juxtaglomerular apparatus. Histopathology 9:783–785
Xiong W, Chao L, Chao J (1989) Renal kallikrein mRNA localization by in situ hybridization. Kidney Int 1324–1329
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gardiner, D.S., Jackson, R. & Lindop, G.B.M. The renin-secreting cell and the glomerular peripolar cell in renal artery stenosis and Addison's disease. Vichows Archiv A Pathol Anat 420, 533–537 (1992). https://doi.org/10.1007/BF01600259
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01600259