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Fluconazole treatment of Candidal infections caused by non-Albicans Candida species

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Abstract

Fluconazole is an effective alternative to amphotericin B for the treatment of serious infections caused byCandida albicans. Through a literature survey of candidal infections caused by non-albicans Candida spp., 43 cases treated with fluconazole were found. The most common causative organisms wereCandida parapsilosis (14 patients),Candida glabrata (12 patients), andCandida tropicalis (11 patients). The dose of fluconazole varied from 50 to 400 mg daily. The median duration of treatment was 21 days. Overall efficacy was 77%. The efficacy against the various species was 93% forCandida parapsilosis, 50% forCandida glabrata, and 82% forCandida tropicalis. In conclusion, fluconazole is effective against the most commonnonalbicans Candida spp., although higher doses may be required for infections caused byCandida glabrata. Infections caused byCandida krusei should not be treated with fluconazole.

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  1. Department of Infectious Diseases, University Hospital Leiden, Building 1, C5P, PO Box 9600, 2300, RC Leiden, The Netherlands

    J. W. van't Wout

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  1. J. W. van't Wout
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van't Wout, J.W. Fluconazole treatment of Candidal infections caused by non-Albicans Candida species. Eur. J. Clin. Microbiol. Infect. Dis. 15, 238–242 (1996). https://doi.org/10.1007/BF01591361

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