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Treatment with cortisone plus heparin or hexuronyl hexoaminoglycan sulfates of murine tumors and their lung deposits

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Abstract

Heparin, cortisone, and combination of these two drugs were used for treatment of solitary tumors and artificial lung metastases of the fibrosarcoma NFSA and the mammary carcinoma MCA-K in C3Hf/Kam mice. Heparin reduced the number of artificial metastases of both tumors, but it did not affect the s.c. growth of these tumors. Conversely, cortisone reduced both the number of artificial metastases and the growth rate of s.c. tumors. The effect of cortisone was not further influenced by heparin. Cortisone showed a tendency for causing enhancement of spontaneous metastases. In addition, two heparin analogs, hexuronyl hexaminoglycan sulfates were studied against MCA-K solitary tumors and their spontaneous metastases. They were ineffective when given alone, and they did not influence the effect of cortisone on the s.c. tumor growth. However, they slightly reduced the cortisone-induced enhancement of spontaneous metastases.

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Author notes

  1. Ivan Basic

    Present address: Department of Animal Physiology, Faculty of Natural Sciences and Mathematics, University of Zagreb, Zagreb, Yugoslavia

Authors and Affiliations

  1. Department of Experimental Radiotherapy, The University of Texas M. D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Luka Milas, Nancy Hunter & Ivan Basic

Authors
  1. Luka Milas
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  2. Nancy Hunter
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  3. Ivan Basic
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Milas, L., Hunter, N. & Basic, I. Treatment with cortisone plus heparin or hexuronyl hexoaminoglycan sulfates of murine tumors and their lung deposits. Clin Exp Metast 3, 247–255 (1985). https://doi.org/10.1007/BF01585080

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  • DOI: https://doi.org/10.1007/BF01585080

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