Summary
Several α,β-unsaturated and aromatic aldehydes were evaluated for antimicrobial activity usingMycobacterium bovis as the test strain. Activity of most of the compounds was determined in the presence and absence of 2% glutaraldehyde. Several compounds highly active against this organism, e.g. 2-pentenal, benzaldehyde, ando-phthalaldehyde showed rapid kill of >105 CFU ml−1 in 5 min. Activity of α,β-unsaturated compounds substituted in the β1 position showed increasing activity with increasing chain length. Of the aromatic aldehydes tested, benzaldehyde andp-dimethylamino benzaldehyde showed little activity alone, but when combined with 2% glutaraldehyde showed increased activity. Substituents added to the benzaldehyde ring (nitro, chloro, methyl, and methoxy) all detracted from the synergism, but still showed increased activity over the activity of 2% glutaraldehyde. The same affect was noted with disubstituted benzaldehyde compounds but not with substitutedo-phthaladehyde (2-formylformaldehyde).
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Gordon, M.D., Ezzell, R.J., Bruckner, N.I. et al. Enhancement of mycobactericidal activity of glutaraldehyde with α,β-unsaturated and aromatic aldehydes. Journal of Industrial Microbiology 13, 77–82 (1994). https://doi.org/10.1007/BF01584102
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DOI: https://doi.org/10.1007/BF01584102