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Umwandlungsformen des Fibrinogens

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Zusammenfassung

Es wird ein Überblick gegeben über die chemischen Eigenschaften von Fibrinogen und Fibrin, über chemische Aspekte der Fibrinogen-Fibrin-Umwandlung und über beschriebene Fibrinogen- und Fibrin-Derivate.

Die erwähnten Eigenschaften vom Fibrinogen und Fibrin sind Molekulargröße, isoelektrischer Punkt, Aminosäuren- und Kohlenhydrate-Zusammensetzung, carboxyl- und amino-terminale Aminosäuren.

Betreffend der Fibrinogen-Fibrin-Umwandlung werden besonders die Isolierung und die Sequenzen der sog. Fibrinopeptide und die Zeitabhängigkeit der Peptid-Abspaltungen besprochen.

Die bis jetzt bekannten chemischen Derivate von Fibrinogen und Fibrin werden erwähnt. Sie waren durch Jodierung, Tyrosinase-Oxydierung, Acetylierung, Guanidierung, Veresterung und Diazotierung hergestellt. Ein neues Derivat, das durch Disulfidbrücken-Spaltung hergestellt war, wird beschrieben. Dieses sog. S-Sulfo-Fibrinogen und S-Sulfo-Fibrin waren beide wasserlöslich und gaben bei Elektrophorese drei Komponenten. Das S-Sulfo-Fibrinogen wurde von Thrombin gespalten.

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Authors and Affiliations

  1. Aus der Chemischen Abteilung II des Karolinska Institutet Stockholm, Sweden

    Birger Blombäck & Agnes Henschen

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  1. Birger Blombäck
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  2. Agnes Henschen
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Vortrag am 3. Marburger Symposium für „Biochemie und Klinik crblicher Proteindefekte“, 6. bis 9. September 1961.

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Blombäck, B., Henschen, A. Umwandlungsformen des Fibrinogens. Klin Wochenschr 41, 78–83 (1963). https://doi.org/10.1007/BF01583739

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