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The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects

Summary

Nineteen obese female subjects with body mass index ranging between 30 and 40 were included in a double-blind crossover study aimed at evaluating the effects of oral 5-hydroxytryptophan administration on feeding behavior, mood state and weight loss. Either 5-hydroxytryptophan (8 mg/kg/day) or placebo was administered for five weeks during which patients were not prescribed any dietary restrictions. Feeding behavior was investigated by means of a questionnaire designed to establish the onset of anorexia and related symptoms. Food intake was evaluated using a three-day diet diary. BDI, SI, STAI-T, and STAI-S were used to assess mood state. The administration of 5-hydroxytryptophan resulted in no changes in mood state but promoted typical anorexiarelated symptoms, decreased food intake and weight loss during the period of observation.

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Ceci, F., Cangiano, C., Cairella, M. et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J. Neural Transmission 76, 109–117 (1989). https://doi.org/10.1007/BF01578751

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Keywords

  • 5-Hydroxytryptophan
  • feeding behavior
  • obesity
  • serotoninergic system
  • tryptophan