Summary
Nocardia lactamdurans, which produces the antibiotics efrotomycin and cephamycin C, exhibits essentially unregulated pyrimidine synthesis. Neither the first nor the second step is subject to feedback regulation. In a series of strains, comprising the original soil isolate, a set of spontaneous fluorouracil-resistant (FUR) mutants and the first improved efrotomycin producer, three of the pyrimidine biosynthetic enzymes were found to be coordinately regulated over a tenfold range. This amplification of enzyme activity accounts for the pyrimidine-related properties but not, at present, for their improved efrotomycin capacity.
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Nielsen, J.B.K. Coordinately elevated pyrimidine biosynthetic enzymes in fluorouracil resistant mutants ofNocardia lactamdurans . Journal of Industrial Microbiology 5, 323–327 (1990). https://doi.org/10.1007/BF01578207
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DOI: https://doi.org/10.1007/BF01578207