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In vitro comparison of ceftazidime, aztreonam, cefpirome, gentamicin, imipenem, enoxacin, and ticarcillin plus clavulanic acid against 108 strains ofPseudomonas maltophilia

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Abstract

Pseudomonas maltophilia is an uncommon cause of hospital-acquired infection and is resistant to most of the antimicrobial agents used in the treatment of gram-negative infections. Susceptibility of 108 isolates ofP. maltophilia to ceftazidime, aztreonam, defpirome, gentamicin, imipenem, enoxacin, and ticarcillin plus clavulanic acid was determined by an agar dilution method. The isolates were in general resistant to the antibiotics. Imipenem and cefpirome were not active at clinically achievable levels. Of the isolates, 20% were susceptible to ≤16 μg/ml ceftazidime, 53% were susceptible to ≤4 μg/ml enoxacin, 10% were susceptible to ≤4 μg/ml gentamicin, and 25% were susceptible to ≤64 μg/ml ticarcillin plus 2 μg/ml clavulanic acid.

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  1. Division of Infectious Diseases, Department of Medicine, University of Kentucky College of Medicine, 40536, Lexington, Kentucky, USA

    Robert C. Noble & Manhar C. Parekh

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  1. Robert C. Noble
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  2. Manhar C. Parekh
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Noble, R.C., Parekh, M.C. In vitro comparison of ceftazidime, aztreonam, cefpirome, gentamicin, imipenem, enoxacin, and ticarcillin plus clavulanic acid against 108 strains ofPseudomonas maltophilia . Current Microbiology 15, 177–179 (1987). https://doi.org/10.1007/BF01577269

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