Abstract
In the clawed toadXenopus laevis, thymectomy at 7 days of age abrogates the phytohemagglutinin response of leukocytes and the mixed leukocyte reaction.
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Ashman, R., Keast, D., Stanley, N.F., and Waring, H.: Thein vitro response to phytohaemagglutinin (PHA) of leucocytes from intact and thymectomized quokkas.Aust. J. Exp. Biol. Med. Sci. 50: 337–345, 1972
Bealmear, P.M. and Wilson, R.: Leucocyte counts of germ free neonatally thymectomized CFW mice.Blood 30: 112–119, 1967
Cole, C.J. and Morris, B.: Homograft rejection and hypersensitivity reactions in lambs thymectomizedin utero.Aust. J. Exp. Biol. Med. Sci. 49: 75–88, 1971
Du Pasquier, L., Chardonnens, X., and Miggiano, V.C.: A major histocompatibility complex in the toadXenopus laevis (Daudin).Immunogenetics 1: 482–494, 1975
Goldshein, S.J. and Cohen, N.: Phylogeny of immunocompetent cells. I. In vitro blastogenesis and mitosis of toad (Bufo marinus) splenic lymphocytes in response to phytohemagglutinin and in mixed lymphocyte cultures.J. Immunol. 108: 1025–1033, 1972
Horton, J.D. and Manning, M.J.: Response to skin allografts inXenopus laevis following thymectomy at early stages of lymphoid organ maturation.Transplantation 14: 141–154, 1972
Manning, M.J.: The effect of early thymectomy on histogenesis of the lymphoid organs inXenopus laevis.J. Embryol. Exp. Morphol. 26: 219–229, 1971
Miggiano, V.C., Meo, T., Birgen, I., and Nabholz, M.: Further miniaturization and automation of in vitro lymphocyte cultures.Tissue Antigens 5: 173–185, 1975
Nieuwkoop, P.D. and Faber, J.: Normal table ofXenopus laevis; p. 163, North Holland Publishing Company, Amsterdam, 1967
Turner, R.J. and Manning, M.J.: Thymic dependence of amphibian antibody response.Eur. J. Immunol. 4: 343–346, 1974
Weiss, N. and Du Pasquier, L.: Factors affecting the reactivity of amphibian lymphocytes in a minaturized technique of the mixed lymphocyte culture.J. Immunol Methods 3: 273–285, 1973
Weiss, N., Horton, J.D., and Du Pasquier, L.: The effect of thymectomy on cell surface associated and serum immunoglobulin in the toadXenopus laevis (Daudin): a possible inhibitory role of the thymus on the expression of immunoglobulins.In L'étude Phylogénique et Ontogénique de La Réponse Immunitaire et Son Apport à La Théorie Immunologique, Inserm Edition Paris; pp. 165–174, 1973
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A project grant from the Medical Research Council to Dr. J.D. Horton is gratefully acknowledged.
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Du Pasquier, L., Horton, J.D. The effect of thymectomy on the mixed leukocyte reaction and phytohemagglutinin responsiveness in the clawed toadXenopus laevis . Immunogenetics 3, 105–112 (1976). https://doi.org/10.1007/BF01576943
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DOI: https://doi.org/10.1007/BF01576943