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Do precursor lesions of prostatic carcinoma exist?

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Summary

On the basis of histological, cytological, and immunohistochemical analysis of routine examination material, the significance of atypical hyperplasia (intraductal dysplasia or intraepithelial neoplasia) and incidental carcinoma was studied to classify precursors of prostatic carcinoma. The preneoplasias showed the following characteristics: an incipient dissolution of the architecture of acinar and ductal structures, with focal destruction of basal cell layers; the formation of cellular atypias of slight, moderate, and severe degrees as well as cytological proof of prominent solitary nucleoli in increasingly eccentric positions; cell kinetically and immunohistochemically, there were similarities to manifest carcinomas, especially in the progressive loss of basal cell layers and keratin expression. Presumably, the peripheral, intraductal, and acinar dysplasias (intraepithelial neoplasia) are precursors of peripheral prostatic carcinoma, with ductal spread via the incidental carcinoma (TIb). The central, atypical adenomatous grade I–III hyperplasias should also be classified as precursors of the central (incidental) carcinoma (TIa).

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Authors and Affiliations

  1. Institute of Pathology, P.O. Box 720, D-7700, Singen, Germany

    B. Helpap

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  1. B. Helpap
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Helpap, B. Do precursor lesions of prostatic carcinoma exist?. World J Urol 7, 27–33 (1989). https://doi.org/10.1007/BF01576841

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