Abstract
In tests with 72 human donors, the outcome of the xenogeneic human-mouse MLR was influenced more by the general capacity of the human responder cells to react than by the MHS genotype of the mouse stimulating cells. While the response of the human lymphocytes of the same donor to the lymphocytes of six congenic mouse strains with differentH-2 haplotypes was generally rather similar, there were pronounced differences among individual human donors in the reactivity in these tests. These differences correlated with HLA, since the low reactivity was associated with the presence of the antigens HLA-AW25, HLA-B18, and HLA-DW2. The effect of the presence of antigens AW25, B18 was much more pronounced in males than in females. The low capacity to react in xenogeneic MLR in individuals with antigens HLA-AW25 and HLA-B18 may be the result of the general immune insufficiency associated with these antigens, which also includes C2 defficiency and association with immunopathological diorders.
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Cukrová, V., Rychlíková, M. & Démant, P. Defective MLR capacitation in the human: Low xenogeneic MLR capacity associated with HLA antigens AW25 B18, and DW2. Immunogenetics 4, 531–540 (1977). https://doi.org/10.1007/BF01575687
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DOI: https://doi.org/10.1007/BF01575687