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Variable effect of anH-21 barrier on response to skin allografts in the mouse

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Abstract

(AQR×B10)F1 mice were grafted with skin from donors differing in theK, I, KI, andISD regions of theH-2 complex. A dichotomy was observed in the fate of theH-2I-disparate grafts: either they were rejected acutely within the second week or were accepted indefinitely. Acceptances were much more common among male than female hosts. Acceptor status was limited to the I group, was unpredictable in occurrence, was not well-correlated with positive serum anti-Ia titers, and did not confer protection of grafts that were alike atH-2I but different atH-2K orH-2D. Since theH-2I barrier studied here elicited such divergent responses in genetically identical hosts, it is unlikely that any histocompatibility typing test could predict graft fate.

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Abbreviations

MST:

median survival time

MHC:

major histocompatibility complex

CTL:

cytotoxic T lymphocyte

B10:

C57 BL/10

6R:

BIO.T(6R)

B10.A:

BIO. ASn

H-2-Ia:

serologically detected antigens coded in theI region ofH-2

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Authors and Affiliations

  1. Immunobiology Research Unit, Departments of Pathology and Human Genetics, University of Pennsylvania School of Medicine, 19174, Philadelphia, Pennsylvania

    William L. Elkins & Willys K. Silvers

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  1. William L. Elkins
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  2. Willys K. Silvers
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Additional information

This term is used in preference toIa, since it has recently been shown that Ia-like alloantigens may be coded outside the MHC (Dickleret al. 1975).

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Elkins, W.L., Silvers, W.K. Variable effect of anH-21 barrier on response to skin allografts in the mouse. Immunogenetics 4, 245–255 (1977). https://doi.org/10.1007/BF01575664

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  • DOI: https://doi.org/10.1007/BF01575664

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