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The genetic control of the immune response to murine histocompatibility antigens

I. The response to H-4 alloantigens

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Abstract

The genetic control of the immune response to H-4 histocompatibility alloantigens is described. The rejection of H-4.2-incompatible skin grafts is regulated by anH-2-linkedIr gene. Fast responsiveness is determined by a dominant allele at theIrH-4.2 locus. TheH-2 b,H-2 d, andH-2 s haplotypes share the fast response allele;H-2 a has the slow response allele. Through the use of intra-H-2 recombinants, we have mapped theIrH-4.2 locus to theI-B subregion of theH-2 complex; theH-2 h4,H-2 15, andH-2 t4 haplotypes are fast responder haplotypes. These observations suggest that the strength of non-H-2 histocompatibility antigens is ultimately determined by the antigen-specific recipient responsiveness.

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Authors and Affiliations

  1. Genetics Curriculum, Department of Bacteriology and Immunology, University of North Carolina, 27514, Chapel Hill, North Carolina

    Peter J. Wettstein & Geoffrey Haughton

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  1. Peter J. Wettstein
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  2. Geoffrey Haughton
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Wettstein, P.J., Haughton, G. The genetic control of the immune response to murine histocompatibility antigens. Immunogenetics 4, 65–78 (1977). https://doi.org/10.1007/BF01575646

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  • DOI: https://doi.org/10.1007/BF01575646

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