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Occurrence of cyclosporins and cyclosporin-like peptolides in fungi


Apart from 17 previously listed fungal taxa producing cyclosporin A and its natural congeners B to Z, several additional and taxonomically diverse strains producing the single novel component [Thr2, Leu5, Leu10]cyclosporin or cyclosporin-like peptolides (eg SDZ 214-103=[Thr2, Leu5, D-Hiv8, Leu10]cyclosporin) have recently been described. We report here the isolation of two further and novel cyclosporins, [Thr2, Leu5, Ala10]cyclosporin (2) and [Thr2, Ile5] cyclosporin (3), from strains classified asAcremonium luzulae (Fuckel) W Gams andLeptostroma anamorph ofHypoderma eucalyptii Cooke & Harkn, respectively. In both new strains the usual pattern of cyclosporins A to Z is not found. The structure elucidations of2 and3 are based on NMR spectroscopy, and biological data (immunosuppressive activity, cyclophilin-binding affinity and antifungal effects) are presented.

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Correspondence to M M Dreyfuss.

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Traber, R., Dreyfuss, M.M. Occurrence of cyclosporins and cyclosporin-like peptolides in fungi. Journal of Industrial Microbiology & Biotechnology 17, 397–401 (1996).

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  • cyclosporins
  • cyclosporin-like peptolides
  • fungal taxa
  • Acremonium luzulae
  • Leptostroma anamorph ofHypoderma eucalyptii