Summary
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1.
A method is presented for alleviating the severity of the metrazol convulsion by the intravenous use of beta-erythroidin hydrochloride.
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2.
Thirty-seven patients were given a total of 156 treatments with 139 resulting convulsions. No roentgenographic or clinical evidence of fractures was found.
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3.
Symptoms of beta-erythroidin hydrochloride overdosage were readily dissipated by the administration of prostigmin.
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4.
This method does not interfere with the usual results of metrazol convulsive therapy in the psychoses.
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References
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Unpublished data.
Rosen, S. R., Ziegler, J. B., and Cominole, B.: Pharmacologic modification of the metrazol convulsion. Jour. Am. Pharm. Ass., 29:164, April, 1940.
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Rosen, S.R., Ewen Cameron, D. & Ziegler, J.B. The prevention of metrazol fractures by beta-erythroidin hydrochloride. Psych Quar 14, 477–480 (1940). https://doi.org/10.1007/BF01573128
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DOI: https://doi.org/10.1007/BF01573128