Abstract
The IgM plaque-forming response to the alpha 1–6 epitope of dextran B512 is linked to the Ig-1 heavy chain allotypes j and b characteristic of CBA and C57BL strains, respectively, and the response typically induces the formation of autoanti-idiotypic antibodies that can distinguish between anti-dextran antibodies of CBA and C57BL origin. Nevertheless, some substrains of Balb/c mice (allotype a) and some Bailey recombinant stains give a PFC response although they do not possess allotypes j or b. The anti-dextran antibodies in these strains lack the idiotypes characteristic of either CBA and C57BL antibodies to dextran, but they possess their own particular idiotype. F1 hybrids between two responder strains possessing different idiotypes on their antibodies against dextran, produce both idiotypes and two different autoanti-idiotypic antibodies. CBA(Ig-1b) mice were high responders to dextran and possessed the idiotype of C57BL, whereas C57BL/6(Ig-1a) mice were low responders. The VH recombinant strains BAB.14 and CB-8KN that possess the Ig-1b allotype of C57BL, but have some of theV H genes from Balb/c and the rest from C57BL/6 were high responders to dextran, but did not possess the C57BL idiotype, suggesting that the genes determining the response against dextran and the idiotype may have different locations in the heavy chain locus.
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Cosenza, H., Julius, M. H., and Augustin, A. A.: Idiotypes as variable region markers: Analogies between receptors on phosphorylcholine-specific T and B lymphocytes.Immunol. Rev. 34: 3–33, 1977
Cosenza, H.: Detection of anti-idiotype reactive cells in the response to phosphorylcholine.Eur. J Immunol. 6: 114–116, 1976
Eichmann, K.: Genetic control of antibody specificity in the mouse.Immunogentics 2: 491–506, 1975
Fernandez, C., Lieberman, R., and Möller, G.: The immune response to the alpha 1–6 epitope of dextran is determined by a gene linked to the IgCH locus.Scand. J Immunol. 10: 77–80, 1979
Fernandez, C. and Möller, G.: The immune response against two epitopes on the same thymus-independent carrier. I. The role of epitope density in carrier-dependent immunity and tolerance.Immunology 33: 59–68, 1977
Fernandez, C. and Möller, G.: Antigen-induced strain-specific autoanti-idiotypic antibodies modulate the immune response to dextran B512.Proc. Natl. Acad. Sci. U.S.A. 76: 5944–5947, 1979a
Fernandez, C. and Möller, G.: A primary immune response to dextran B512 is followed by a period of antigen-specific immunosuppression caused by autoanti-idiotypic antibodies.Scand. J. Immunol. 11: 53–57, 1979a
Hopper, J. E. and Nisonoff, A.: Individual antigenic specificity of immunoglobulins.Adv. Immunol. 13: 58–101, 1971
Howard, J. G.: Induction of B cell tolerance by exhaustive immunization and during immunosuppression.Eur. J. Immunol. 4: 603–606, 1974
Howard, J. G., Vicari, G., and Courtenay, B. M.: Influence of molecular structure on the tolerogenicity of bacterial dextrans. I. The alpha 1–6 linkedepitope of dextran B512.Immunology 29: 585–595, 1975
Kolb, C., Weiler, E., Seppälä, I., Eichmann, K., Kaartinen, M., Pelkonen, J., Karjalainen, K., and Mäkelä, O.: A cross-over chromosome combiningIg heavy chain genes of two mouse strains.Immunogenetics 9: 455–463, 1979
Köhler, H.: The response to phosphorylcholine: dissecting an immune response.Transplant. Rev. 27: 24–56, 1975
Liebermann, R., Potter, M., Humphrey, W., and Chien, C. C.: Idiotypes of inulin binding antibodies and myeloma proteins controlled by genes linked to the allotype locus of the mouse.J. Immunol 117: 2105–2111, 1976
Möller, G.: Idiotypes on T and B cells.Immunol. Rev. 34: 1–164, 1977
Potter, M.: Antigen-binding myeloma proteins in mice.Ann. N. Y. Acad. Sci. 190: 306–316, 1971
Riblet, R., Weigert, M., and Mäkelä, O.: Genetics of mouse antibodies. II. Recombination between VH genes and allotype.Eur. J. Immunol. 5: 778–791, 1979
Schrater, A. F., Goidl, E. A. Thorebecke, J., Siskind, G. W.: Production of autoanti-idiotypic antibody during the normal immune response to TNP-Ficoll. I. Occurrence in AKR/J and Balb/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.J. Exp. Med. 150: 138–153, 1979
Vicary, G. and Courtenay, B. M.: Restricted avidity of the IgM antibody response to dextran B512 in mice: studies on inhibition of specific PFC by oligosaccharides.Immunochemistry 14: 253–258, 1977
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Fernandez, C., Mäkelä, O. & Möller, G. Genetics of the anti-dextran B512 and the autoanti-idiotypic response: Codominant expression in F1 hybrids and dichotomy of response and allotype-linked idiotype. Immunogenetics 10, 573–582 (1980). https://doi.org/10.1007/BF01572591
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DOI: https://doi.org/10.1007/BF01572591