Abstract
Among several inbred strains of mice studied, only C3H/HeJ failed to demonstrate LPS enhancement of antibody response to the synthetic polypeptide (T,G)-A-L. LPS antibody enhancement was designated the LPS/adjv(+) trait and results of testing F1 and backcross animals were consistent with the postulate that the LPS/adjv(+) trait may be determined by a single autosomal dominant gene.
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Abbreviations
- LPS:
-
lipopolysaccharide
- (T,G)-A-L:
-
poly-L-(tyrosine, glutamic acid)-poly-D,L-alanine-poly-L-lysine
- (H,G)-A -L:
-
poly-L-(histidine, glutamic acid)-poly-D,L-alanine-poly-L-lysine
- (Phe,G)-A -L:
-
poly-L-(phenylalanine, glutamic acid)-poly-D,L-alanine-poly-L-lysine
- PBS:
-
phosphatebuffered saline
- 2MeR:
-
2-mercaptoethanol-resistant
- T-cell:
-
thymusderived lymphocyte
- B-cell:
-
bone marrow derived lymphocyte
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Talcott, J.A., Ness, D.B. & Grumet, F.C. Adjuvant effect of LPS on in vivo antibody response: Genetic defect in C3H/HeJ mice. Immunogenetics 2, 507–515 (1975). https://doi.org/10.1007/BF01572319
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DOI: https://doi.org/10.1007/BF01572319