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Genetic control of antibody specificity in the mouse

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Abstract

Genetic markers related to the antigen binding specificity of mouse immunoglobulins (idiotypes and fine specificity characteristics) are used to investigate the polymorphism of genes encoding heavy chain variable regions (V H genes). The distribution of eight such specificity related markers in inbred strains and their segregation together with allotype indicate linkage to genes that specify the heavy chain constant regions (C H genes). A number of recombinant mice allowed the construction of a chromosomal map consisting of threeV H subloci, oneC h sublocus, and a region which contains nonimmunoglobulin coding genes. All data are consistent with a linear arrangement of genes in this linkage group so thatV H andC H genes are discontinuous. Each of theV H subloci is correlated to a particular set of antigen binding specificities which include protein antigens, polysaccharides, and haptens. This suggests that specific complementarity determining sequence portions are conserved in the germ line of the mouse.

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  1. Institute for Genetics, University of Cologne, Cologne, W.-Germany

    Klaus Eichmann

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Eichmann, K. Genetic control of antibody specificity in the mouse. Immunogenetics 2, 491–506 (1975). https://doi.org/10.1007/BF01572318

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