Abstract
Recombinant strains of mice with known alleles in theI region of theH-2 complex were used to map theH-2 linked immune response genes controlling responsiveness to random terpolymers GAT10 and GLΦ. TheIr-GAT gene was mapped to either theIA orIB subregions. In contrast, data obtained in the GLΦ-GLT system indicated multigenic control. The responsiveness of the B10.A(3R), B10.A(5R), and B10.S(9R) recombinants indicated that one immune response gene,IrGLΦ-GLT A, mapped to the right ofIB, i.e., in theIC subregion. The nonresponsiveness of the B10.A(1R), B10.A(2R), B10.M(17R), and AQR mice having responderIC d alleles butIA k-IB k nonresponder alleles and the positive response of a (C57BL/6 × A/J)F1 hybrid derived from two nonresponder parental strains indicated the presence of a second gene inIA-IB subregions,Ir-GLΦ-GLT B. The interaction between these two genes, each present in a differentI subregion, controls the immune response.
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Merryman, C.F., Maurer, P.H. & Stimpfling, J.H. Unigenic and multigenicI region control of the immune responses of mice to the GAT10 and GLΦ-GLT terpolymers. Immunogenetics 2, 441–448 (1975). https://doi.org/10.1007/BF01572314
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DOI: https://doi.org/10.1007/BF01572314