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Immune response to calf collagen type I in mice: A combined control ofIr-1A and nonH-2 linked genes

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Abstract

The genetically controlled immune response to calf skin collagen type I in mice could be demonstrated to be governed by at least two genes. One is linked to theH-2 complex and located within theIA subregion. High-responder alleles areH-2 b,H-2 f, andH-2 s. The other gene(s) is not linked to theH-2 complex and high-responder allele(s) are found in the genome of B10 mice but not in the genome of DBA mice. There are strong indications that theIr-1A gene controls the response at the T-cell level, whereas it is assumed that the background gene(s) control the immune response at a different level.

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Authors and Affiliations

  1. Max-Planck-Institut für Biochemie, Martinsried b. München, Germany

    Hans Nowack & Rupert Timpl

  2. Medizinische Universitätsklinik, Marburg/Lahn, Germany

    Eckhart Hahn

  3. Department of Human Genetics, The University of Michigan, Ann Arbor, Michigan, USA

    Chella S. David

  4. Abteilung Immunologie des Instituts für Hämatologie der GSF, München, Germany

    Dietrich Götze

Authors
  1. Hans Nowack
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  2. Eckhart Hahn
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  3. Chella S. David
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  4. Rupert Timpl
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  5. Dietrich Götze
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Nowack, H., Hahn, E., David, C.S. et al. Immune response to calf collagen type I in mice: A combined control ofIr-1A and nonH-2 linked genes. Immunogenetics 2, 331–335 (1975). https://doi.org/10.1007/BF01572302

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  • DOI: https://doi.org/10.1007/BF01572302

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