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Study ofH-2 mutations in mice VI. M523, a newK end mutant

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Abstract

A newH-2 mutation was found in a mouse belonging to CBA/CaLacSto (H-2 k) strain and designated 523, the proposed haplotype symbol for which isH-2 ka. The line CBA.M523 carries this mutation and is fully congenic with the parental strain, except for the mutant site 523. The mutation 523 is located within theK- end of theH-2 gene complex. Phenotypically, it causes prompt skin graft rejection and pronounced graft-versus-host activity in strain combination CBA/Sto⇄C-BA.M523. Attempts to produce active alloantisera in the same strain combination have so far been unsuccessful.

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Authors and Affiliations

  1. Yurlovo Department of Genetics, Laboratory of Experimental Animals, Academy of Medical Sciences, Moscow Region, USSR

    Zinaida Blandova

  2. Institute of General Genetics, USSR Academy of Sciences, 117312, Moscow, USSR

    Yuri A. Mnatsakanyan & Igor K. Egorov

Authors
  1. Zinaida Blandova
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  2. Yuri A. Mnatsakanyan
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  3. Igor K. Egorov
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Blandova, Z., Mnatsakanyan, Y.A. & Egorov, I.K. Study ofH-2 mutations in mice VI. M523, a newK end mutant. Immunogenetics 2, 291–295 (1975). https://doi.org/10.1007/BF01572297

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  • DOI: https://doi.org/10.1007/BF01572297

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