Abstract
The primary immune response to the Thy-1.1 antigen was measured by a plaque assay that detected cells producing antibodies lytic for AKR thymocytes. B10.129(6M) mice carrying theH-2 complex of an intermediate responder (129) on a low-responder (B10) background, were low responders. Studies employing different F1 hybrids and segregating generations of 129/J and 6M mice indicated that differences in responsiveness of those two strains depend on alleles at a single locus, loosely linked to theH-2 complex. These results lend further support to the previously advanced concept that the expression of theIr-Thy-1 allcles controlling the response to the Thy-1.1 antigen is influenced by the alleles at theIr-5 locus. In addition, studies employing F1 hybrids produced through matings of 129/J, 6M, C3H.B10 and C57BL/6J mice to a panel of inbred strains suggested that in regard to the responsiveness to the Thy-1.1 antigen, 129/J and 6M mice are phenotypically, and presumably genotypically, similar to C3H.B10 and C57BL/6J mice, respectively.
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Fuji, H., Zaleski, M., and Milgrom, F.: Genetic control of immune response toθ AKR alloantigen.J. Immunol. 108:223–230, 1972
Fuji, H., Zaleski, M., and Milgrom, F.: Immune response to alloantigens of thymus studied in mice with plaque assay.J. Immunol. 106:56–64, 1971
Gershon, R.K., Merryman, C.F., and Maurer, P.H.: A cellular basis for genetically controlled immunologie unresponsiveness. Tolerance induction in T cells.Fed. Proc. 31:778, 1972
Gorer, P.A. and Mikulska, Z.B.: The antibody response to tumor inoculation. Improved methods of antibody detection.Cancer Res. 14:651–655, 1954
Götze, D., Reisfeld, R.A., and Klein, J.: Serological evidence of antigens controlled by theIr region in mice.J. Exp. Med. 138:1003–1008, 1973
Hämmerling, G.J., Deak, B.D., Mauve, G., Hämmerling, V., and McDevitt, H.O.: B lymphocyte alloantigens controlled by theI region of the major histocompatibility region in mice.Immunogenetics 1:68–81, 1974
Hauptfeld, V., Klein, D., and Klein, J.: Serological identification of anIr region product.Science 181:167–169, 1973
Mozes, E., Shearer, G.M., Maron, E., Aron, R., and Sela, M.: Cellular studies of the genetic control of immune response toward the loop region of lysozyme.J. Immunol. 111:1429–1433, 1973a
Mozes, E., Shearer, G.M., Sela, M., and Braun, W.: Genetic control of immune responses to synthetic polypeptides in mice. Cellular analysis of the phenotypic correction of theIr-3 gene defect by poly-adenylic-poly-uridylic acid.J. Immunol. 111:439–447, 1973 b
Ordal, J.C. and Grumet, F.C.: The effect of graft-versus-host reaction on the antibody response to poly-L (TYR, Glu)-poly D, L-ALA-poly-L-LYS in non responder mice.J. Exp. Med. 136:1195 1206, 1972
Vaz, N.M., De Souza, C.M., and Sauerbronn Maia, L.C.: Genetic control of immune responsiveness to ovalbumin in (C57BL×DBA/2)F1 mice.Int. Arch. Allergy 46:215–219, 1974
Zaleski, M.: Immune response of mice to Thy-1.1 antigen: Studies on congenic lines.Immunogenetics 1:226–238, 1974
Zaleski, M. and Klein, J.: Immune response of mice to Thy-1.1 antigen: Genetic control by alleles at the Ir-5 locus loosely linked to theH-2 complex.J. Immunol. 113:1170–1177, 1974
Zaleski, M. and Milgrom, F.: Complementary genes controlling immune response toθ-AKR antigen in mice.J. Immunol. 110:1238–1244, 1973
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Zaleski, M.B. Immune response of mice to the Thy-1.1 antigen: Effect of theIr-5 alleles studied in 129/J and B10.129 (6M) mice. Immunogenetics 2, 241–248 (1975). https://doi.org/10.1007/BF01572292
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DOI: https://doi.org/10.1007/BF01572292